TCF4 - Transcription factor 4 - human protein (Function)
 
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TCF4 »  Transcription factor 4
 
Gene name:  TCF4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
2
  • IDAMGI
  • IDAUniProtKB
E-box bindingdefinition[GO:0070888]  
1
  • ISSBHF-UCL
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • NASUniProtKB
  • ISSOrtholog Curator
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • ISSBHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • ISSBHF-UCL
Sequence-specific DNA binding RNA polymerase recruiting transcription factor activitydefinition[GO:0001011]  
1
  • ISSBHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • IDABHF-UCL
  • IDAUniProtKB
TFIIB-class binding transcription factor activitydefinition[GO:0001087]  
1
  • ISSBHF-UCL
TFIIB-class transcription factor bindingdefinition[GO:0001093]  
1
  • ISSBHF-UCL
GO biological process 
DNA-templated transcription, initiationdefinition[GO:0006352]  
1
  • ISSBHF-UCL
Positive regulation of neuron differentiationdefinition[GO:0045666]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • ISSBHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Protein-DNA complex assemblydefinition[GO:0065004]  
1
  • ISSBHF-UCL
Transcription initiation from RNA polymerase II promoterdefinition[GO:0006367]  
1
  • ISSBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
HTLV-I infection  hsa05166+6925  
According to Reactome, this protein belongs to the following pathway:
CDO in myogenesis  REACT_21402  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TCF4
GenomeRNAi: 6925
PRO: PR:P15884