RAG1 - V(D)J recombination-activating protein 1 - human protein (Sequence)
 
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RAG1 »  V(D)J recombination-activating protein 1  (RAG-1)
 
Protein also known as:  RING finger protein 74.
Gene name:  RAG1
Family name: RAG1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 76 1
GENE REF ISO

Displayed isoform: Iso 1

 
 
Isoform Iso 1   1043 aaMass: 119097 Da,  pI: 8.94
MAASFPPTLG LSSAPDEIQH PHIKFSEWKF KLFRVRSFEK TPEEAQKEKK DSFEGKPSLE QSPAVLDKAD GQKPVPTQPL LKAHPKFSKK FHDNEKARGK AIHQANLRHL CRICGNSFRA DEHNRRYPVH GPVDGKTLGL LRKKEKRATS WPDLIAKVFR IDVKADVDSI HPTEFCHNCW SIMHRKFSSA PCEVYFPRNV TMEWHPHTPS CDICNTARRG LKRKSLQPNL QLSKKLKTVL DQARQARQHK RRAQARISSK DVMKKIANCS KIHLSTKLLA VDFPEHFVKS ISCQICEHIL ADPVETNCKH VFCRVCILRC LKVMGSYCPS CRYPCFPTDL ESPVKSFLSV LNSLMVKCPA KECNEEVSLE KYNHHISSHK ESKEIFVHIN KGGRPRQHLL SLTRRAQKHR LRELKLQVKA FADKEEGGDV KSVCMTLFLL ALRARNEHRQ ADELEAIMQG KGSGLQPAVC LAIRVNTFLS CSQYHKMYRT VKAITGRQIF QPLHALRNAE KVLLPGYHHF EWQPPLKNVS SSTDVGIIDG LSGLSSSVDD YPVDTIAKRF RYDSALVSAL MDMEEDILEG MRSQDLDDYL NGPFTVVVKE SCDGMGDVSE KHGSGPVVPE KAVRFSFTIM KITIAHSSQN VKVFEEAKPN SELCCKPLCL MLADESDHET LTAILSPLIA EREAMKSSEL MLELGGILRT FKFIFRGTGY DEKLVREVEG LEASGSVYIC TLCDATRLEA SQNLVFHSIT RSHAENLERY EVWRSNPYHE SVEELRDRVK GVSAKPFIET VPSIDALHCD IGNAAEFYKI FQLEIGEVYK NPNASKEERK RWQATLDKHL RKKMNLKPIM RMNGNFARKL MTKETVDAVC ELIPSEERHE ALRELMDLYL KMKPVWRSSC PAKECPESLC QYSFNSQRFA ELLSTKFKYR YEGKITNYFH KTLAHVPEII ERDGSIGAWA SEGNESGNKL FRRFRKMNAR QSKCYEMEDV LKHHWLYTSK YLQKFMNAHN ALKTSGFTMN PQASLGDPLG IEDSLESQDS MEF

Sequence

 show evidences
Domain 
The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity (By similarity).  
1
  • CuratedUniProtKB
The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp (By similarity).  
1
  • CuratedUniProtKB
PTM 
Autoubiquitinated in the presence of CDC34/UBCH3 (By similarity).  
  • CuratedUniProtKB
Sequence caution 
The sequence AAM77798 differs from that shown. Reason: erroneous gene model prediction.  
1
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Polymorphism  definition   [KW-0621]
Domain 
Zinc-finger  definition   [KW-0863]
PTM 
Isopeptide bond  definition   [KW-1017]
Ubl conjugation  definition   [KW-0832]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 3.30.40.10
Gene3D: 3.30.160.60
InterPro: IPR001841 [ Znf RING ]
InterPro: IPR018957 [ Znf C3HC4 RING-type ]
InterPro: IPR015880 [ Znf C2H2-like ]
InterPro: IPR019485 [ Znf VDJ recomb-activ 1 ]
InterPro: IPR017907 [ Znf RING CS ]
InterPro: IPR024627 [ RAG1 ]
InterPro: IPR023336 [ RAG nonamer-bd dom ]
InterPro: IPR013087 [ Znf C2H2/integrase DNA-bd ]
InterPro: IPR013083 [ Znf RING/FYVE/PHD ]
PANTHER: PTHR11539 [ PTHR11539 ]
Pfam: PF12940 [ RAG1 ]
Pfam: PF10426 [ zf-RAG1 ]
Pfam: PF00097 [ zf-C3HC4 ]
PROSITE: PS00518 [ ZF RING 1 ]
PROSITE: PS51487 [ NBD ]
PROSITE: PS50089 [ ZF RING 2 ]
SMART: SM00355 [ ZnF C2H2 ]
SMART: SM00184 [ RING ]
Genome annotation databases
Ensembl: Transcript: ENST00000299440;  Protein: ENSP00000299440;  Gene: ENSG00000166349.
Ensembl: Transcript: ENST00000534663;  Protein: ENSP00000434610;  Gene: ENSG00000166349.
KEGG: hsa:5896
UCSC: uc001mwu.4
Organism-specific databases
MGI: MGI:97848 [ Rag1 ]
PTM databases
PhosphoSite: P15918
Phylogenomic databases
eggNOG: NOG45367
HOGENOM: HOG000232009
HOVERGEN: HBG003861
InParanoid: P15918
KO: K10628
OMA: TIAKRFR
PhylomeDB: P15918
Sequence databases
CCDS: CCDS7902.1 [ P15918-1 ]
EMBL: Genomic DNA:  AY130302 . Translation:  AAM77798.1 . Sequence problems.
EMBL: Genomic DNA:  AC139427 . No translation available.
EMBL: mRNA:  M29474 . Translation:  AAA60248.1 .
IPI: IPI00013914
PIR: A33754
RefSeq: Protein:  NP_000439.1. Nucleotide sequence:  NM_000448.2.
RefSeq: Protein:  XP_005253098.1. Nucleotide sequence:  XM_005253041.1.
UniProtKB: P15918 [ RAG1 ]