DSP - Desmoplakin - human protein (Function)
 
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DSP »  Desmoplakin  (DP)
 
Protein also known as:  250/210 kDa paraneoplastic pemphigus antigen.
Gene name:  DSP
Family name: Plakin or cytolinker
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.  
1
  • UniProtKB
GO molecular function 
Cell adhesion molecule bindingdefinition[GO:0050839] silver  
1
  • InterPro 2 GO
Cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communicationdefinition[GO:0086083]  
1
  • BHF-UCL
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • UniProtKB
  • BHF-UCL
  • IntAct
Protein binding, bridgingdefinition[GO:0030674]  
1
  • UniProtKB
Protein kinase C bindingdefinition[GO:0005080]  
1
  • BHF-UCL
Scaffold protein bindingdefinition[GO:0097110]  
1
  • BHF-UCL
Structural constituent of cytoskeletondefinition[GO:0005200]  
1
  • PINC
Structural molecule activitydefinition[GO:0005198]  
1
  • UniProtKB
GO biological process 
Adherens junction organizationdefinition[GO:0034332] silver  
1
  • Ortholog Compara
Bundle of His cell-Purkinje myocyte adhesion involved in cell communicationdefinition[GO:0086073]  
1
  • BHF-UCL
Desmosome organizationdefinition[GO:0002934]  
1
  • BHF-UCL
Epidermis developmentdefinition[GO:0008544]  
1
  • PINC
Intermediate filament organizationdefinition[GO:0045109]  
1
  • BHF-UCL
Keratinocyte differentiationdefinition[GO:0030216]  
1
  • UniProtKB
Peptide cross-linkingdefinition[GO:0018149]  
1
  • UniProtKB
Protein localization to adherens junctiondefinition[GO:0071896]  
1
  • BHF-UCL
Regulation of heart rate by cardiac conductiondefinition[GO:0086091]  
1
  • BHF-UCL
Regulation of ventricular cardiac muscle cell action potentialdefinition[GO:0098911]  
1
  • BHF-UCL
Ventricular compact myocardium morphogenesisdefinition[GO:0003223]  
1
  • BHF-UCL
Wound healingdefinition[GO:0042060] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+1832  
According to Reactome, this protein belongs to the following pathway:
Apoptotic cleavage of cell adhesion proteins  REACT_13579  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Desmoplakin
GenomeRNAi: 1832
PRO: PR:P15924