MUC1 - Mucin-1 - human protein (Function)
 
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MUC1 »  Mucin-1  (MUC-1)
 
Protein also known as:  Tumor-associated epithelial membrane antigen (EMA); CD antigen CD227. Cleaved into:  Mucin-1 subunit alpha; Mucin-1 subunit beta.
Gene name:  MUC1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.  
9
  • CuratedUniProtKB
The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.  
9
  • CuratedUniProtKB
GO molecular function 
P53 bindingdefinition[GO:0002039]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • IDABHF-UCL
Transcription cofactor activitydefinition[GO:0003712]  
1
  • IDABHF-UCL
GO biological process 
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestdefinition[GO:0006977]  
1
  • IDABHF-UCL
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatordefinition[GO:0006978]  
1
  • IDABHF-UCL
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatordefinition[GO:1902166]  
1
  • IDABHF-UCL
Negative regulation of transcription by competitive promoter bindingdefinition[GO:0010944]  
1
  • IDABHF-UCL
Positive regulation of histone H4 acetylationdefinition[GO:0090240]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoter in response to stressdefinition[GO:0036003]  
1
  • IDABHF-UCL
Regulation of transcription from RNA polymerase II promoter in response to stressdefinition[GO:0043618]  
1
  • IDABHF-UCL
Enzymatic activity 
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
O-linked glycosylation of mucins  REACT_115606  
Termination of O-glycan biosynthesis  REACT_115835  
Caution 
O-glycosylation sites are annotated in first sequence repeat only. Residues at similar position are probably glycosylated in all repeats. Experimental sites were determined in a synthetic peptide glycosylated in vitro (PubMed7744025, PubMed9597769).  
2
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MUC1
GenomeRNAi: 4582
PRO: PR:P15941