GATA1 - Erythroid transcription factor - human protein (Function)
 
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Protein
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References

 
GATA1 »  Erythroid transcription factor
 
Protein also known as:  NF-E1 DNA-binding protein.
Gene name:  GATA1
Entry whose protein(s) existence is based on evidence at protein level
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1 160 3
GENE REF ISO

Function

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Overview 
Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells.  
1
  • CuratedUniProtKB
GO molecular function 
C2H2 zinc finger domain bindingdefinition[GO:0070742]  
1
  • IPIBHF-UCL
Chromatin DNA bindingdefinition[GO:0031490]  
1
  • IDAUniProtKB
DNA bindingdefinition[GO:0003677]  
3
  • IDAUniProtKB
  • IDABHF-UCL
  • IDAMGI
DNA binding, bendingdefinition[GO:0008301] silver  
  • IEAOrtholog Compara
Enhancer sequence-specific DNA bindingdefinition[GO:0001158] silver  
  • IEAOrtholog Compara
P53 bindingdefinition[GO:0002039] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIBHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
  • IEAOrtholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001078]  
1
  • IDABHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
  • IEAOrtholog Compara
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • IDABHF-UCL
RNA polymerase II transcription factor bindingdefinition[GO:0001085]  
2
  • IPIBHF-UCL
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IMPBHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDABHF-UCL
Transcription regulatory region sequence-specific DNA bindingdefinition[GO:0000976]  
1
  • IMPBHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Basophil differentiationdefinition[GO:0030221]  
1
  • IEPBHF-UCL
Cell-cell signalingdefinition[GO:0007267] silver  
  • IEAOrtholog Compara
Cellular response to thyroid hormone stimulusdefinition[GO:0097067]  
1
  • IDAUniProtKB
Dendritic cell differentiationdefinition[GO:0097028] silver  
  • IEAOrtholog Compara
Embryonic hemopoiesisdefinition[GO:0035162] silver  
  • IEAOrtholog Compara
Eosinophil differentiationdefinition[GO:0030222]  
1
  • IEPBHF-UCL
Eosinophil fate commitmentdefinition[GO:0035854]  
1
  • IDABHF-UCL
Erythrocyte developmentdefinition[GO:0048821]  
1
  • IMPBHF-UCL
Erythrocyte differentiationdefinition[GO:0030218]  
1
  • IEPBHF-UCL
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Male gonad developmentdefinition[GO:0008584]  
1
  • IMPBHF-UCL
Megakaryocyte differentiationdefinition[GO:0030219]  
1
  • IMPBHF-UCL
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IMPUniProtKB
Negative regulation of bone mineralizationdefinition[GO:0030502] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240]  
1
  • IMPBHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDAUniProtKB
Negative regulation of transcription regulatory region DNA bindingdefinition[GO:2000678]  
1
  • IDABHF-UCL
Platelet aggregationdefinition[GO:0070527]  
1
  • IMPBHF-UCL
Platelet formationdefinition[GO:0030220]  
3
  • IMPBHF-UCL
Positive regulation of erythrocyte differentiationdefinition[GO:0045648]  
1
  • IMPUniProtKB
Positive regulation of osteoblast proliferationdefinition[GO:0033690] silver  
  • IEAOrtholog Compara
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • IMPBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Regulation of definitive erythrocyte differentiationdefinition[GO:0010724]  
2
  • IDABHF-UCL
Regulation of glycoprotein biosynthetic processdefinition[GO:0010559]  
1
  • IMPBHF-UCL
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • IDABHF-UCL
Transcriptional activation by promoter-enhancer loopingdefinition[GO:0071733]  
  • ISSOrtholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GATA1
GenomeRNAi: 2623
PRO: PR:P15976