ALOX15 - Arachidonate 15-lipoxygenase - human protein (Function)
 
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ALOX15 »  Arachidonate 15-lipoxygenase   [ EC 1.13.11.33 ]  (15-LOX)
 
Protein also known as:  Arachidonate 12-lipoxygenase, leukocyte-type [EC 1.13.11.31] (12-LOX).
Gene name:  ALOX15
Family name: Lipoxygenase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. Beside its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.  
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  • CuratedUniProtKB
GO molecular function 
Arachidonate 12-lipoxygenase activitydefinition[GO:0004052]  
1
  • IDAUniProtKB
Arachidonate 15-lipoxygenase activitydefinition[GO:0050473]  
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  • IDAUniProtKB
Iron ion bindingdefinition[GO:0005506]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
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  • IPIUniProtKB
GO biological process 
Apoptotic cell clearancedefinition[GO:0043277]  
  • ISSOrtholog Curator
Arachidonic acid metabolic processdefinition[GO:0019369]  
2
  • IDAUniProtKB
Bone mineralizationdefinition[GO:0030282]  
  • ISSOrtholog Curator
Cellular response to interleukin-13definition[GO:0035963]  
1
  • IMPUniProtKB
Hepoxilin biosynthetic processdefinition[GO:0051122]  
  • ISSOrtholog Curator
Inflammatory responsedefinition[GO:0006954]  
1
  • TASPINC
Lipoxin A4 biosynthetic processdefinition[GO:2001303]  
  • ISSOrtholog Curator
Lipoxygenase pathwaydefinition[GO:0019372]  
1
  • IDAUniProtKB
Negative regulation of adaptive immune responsedefinition[GO:0002820]  
  • ISSOrtholog Curator
Ossificationdefinition[GO:0001503]  
  • ISSOrtholog Curator
Phosphatidylethanolamine biosynthetic processdefinition[GO:0006646]  
  • ISSOrtholog Curator
Positive regulation of actin filament polymerizationdefinition[GO:0030838]  
  • ISSOrtholog Curator
Positive regulation of cell-substrate adhesiondefinition[GO:0010811]  
1
  • IDAUniProtKB
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • IMPUniProtKB
Regulation of engulfment of apoptotic celldefinition[GO:1901074]  
  • ISSOrtholog Curator
Regulation of peroxisome proliferator activated receptor signaling pathwaydefinition[GO:0035358]  
  • ISSOrtholog Curator
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
  • ISSOrtholog Curator
Wound healingdefinition[GO:0042060]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 1.13.11.31: Arachidonate + O(2) (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.  
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  • CuratedUniProtKB
EC 1.13.11.33: Arachidonate + O(2) (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.  
1
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 iron ion per subunit (By similarity).  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Arachidonic acid metabolism  hsa00590+246  
Linoleic acid metabolism  hsa00591+246  
Metabolic pathways  hsa01100+246  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Dioxygenase  definition   [KW-0223]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ALOX15
GenomeRNAi: 246
PRO: PR:P16050