NPR1 - Atrial natriuretic peptide receptor 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
NPR1 »  Atrial natriuretic peptide receptor 1   [ EC 4.6.1.2 ]
 
Protein also known as:  Atrial natriuretic peptide receptor type A (ANP-A).
Gene name:  NPR1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 68 1
GENE REF ISO

Function

 show evidences
Overview 
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAInterPro 2 GO
G-protein coupled peptide receptor activitydefinition[GO:0008528]  
1
  • NASUniProtKB
GTP bindingdefinition[GO:0005525] silver  
  • IEAOrtholog Compara
Guanylate cyclase activitydefinition[GO:0004383]  
1
  • IDAUniProtKB
Hormone bindingdefinition[GO:0042562]  
2
  • IPIUniProtKB
Natriuretic peptide receptor activitydefinition[GO:0016941]  
2
  • IDAUniProtKB
Peptide hormone bindingdefinition[GO:0017046] silver  
  • IEAOrtholog Compara
Protein kinase activitydefinition[GO:0004672] silver  
  • IEAInterPro 2 GO
Protein kinase bindingdefinition[GO:0019901] silver  
  • IEAOrtholog Compara
GO biological process 
Body fluid secretiondefinition[GO:0007589]  
1
  • TASUniProtKB
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • NASUniProtKB
cGMP biosynthetic processdefinition[GO:0006182]  
1
  • IDAUniProtKB
Dopamine metabolic processdefinition[GO:0042417] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • NASGOC
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAOrtholog Compara
Negative regulation of angiogenesisdefinition[GO:0016525]  
1
  • TASUniProtKB
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • NASUniProtKB
Negative regulation of smooth muscle cell proliferationdefinition[GO:0048662] silver  
  • IEAOrtholog Compara
Positive regulation of cGMP biosynthetic processdefinition[GO:0030828] silver  
  • IEAOrtholog Compara
Positive regulation of renal sodium excretiondefinition[GO:0035815]  
1
  • TASUniProtKB
Positive regulation of urine volumedefinition[GO:0035810]  
1
  • TASUniProtKB
Receptor guanylyl cyclase signaling pathwaydefinition[GO:0007168]  
1
  • IDAUniProtKB
Regulation of blood pressuredefinition[GO:0008217]  
1
  • NASUniProtKB
Regulation of blood vessel sizedefinition[GO:0050880]  
  • IEAUniProtKB KW
Regulation of vascular permeabilitydefinition[GO:0043114]  
1
  • TASUniProtKB
Regulation of vasodilationdefinition[GO:0042312]  
1
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.2: GTP 3',5'-cyclic GMP + diphosphate.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Purine metabolism  hsa00230+4881  
Vascular smooth muscle contraction  hsa04270+4881  
 

Keywords

Biological process 
cGMP biosynthesis  definition   [KW-0141]
Molecular function 
Lyase  definition   [KW-0456]
Receptor  definition   [KW-0675]
Vasoactive  definition   [KW-0838]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: NPR1
GenomeRNAi: 4881
PRO: PR:P16066
Chemistry
GuidetoPHARMACOLOGY: 1747