CD44 - CD44 antigen - human protein (Function)
 
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Protein
Gene
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CD44 »  CD44 antigen
 
Protein also known as:  GP90 lymphocyte homing/adhesion receptor; CD antigen CD44.
Gene name:  CD44
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.  
2
  • UniProtKB
GO molecular function 
Collagen bindingdefinition[GO:0005518]  
1
  • UniProtKB
Contributes to cytokine receptor activitydefinition[GO:0004896]  
1
  • BHF-UCL
Hyaluronic acid bindingdefinition[GO:0005540]  
3
  • UniProtKB
Hyalurononglucosaminidase activitydefinition[GO:0004415]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
GO biological process 
Branching involved in prostate gland morphogenesisdefinition[GO:0060442] silver  
1
  • Ortholog Compara
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
1
  • Ortholog Compara
Cartilage developmentdefinition[GO:0051216]  
1
  • UniProtKB
Cell-matrix adhesiondefinition[GO:0007160]  
1
  • UniProtKB
Cellular response to fibroblast growth factor stimulusdefinition[GO:0044344]  
1
  • UniProtKB
Hyaluronan catabolic processdefinition[GO:0030214]  
1
  • UniProtKB
Monocyte aggregationdefinition[GO:0070487]  
1
  • UniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154]  
1
  • UniProtKB
Negative regulation of DNA damage response, signal transduction by p53 class mediatordefinition[GO:0043518]  
1
  • BHF-UCL
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatordefinition[GO:1902166]  
1
  • BHF-UCL
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • BHF-UCL
Positive regulation of gene expressiondefinition[GO:0010628] silver  
1
  • Ortholog Compara
Positive regulation of heterotypic cell-cell adhesiondefinition[GO:0034116]  
1
  • UniProtKB
Positive regulation of monocyte aggregationdefinition[GO:1900625]  
1
  • BHF-UCL
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
1
  • BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • BHF-UCL
Single organismal cell-cell adhesiondefinition[GO:0016337]  
1
  • UniProtKB
Wnt signaling pathwaydefinition[GO:0016055] silver  
1
  • Ortholog Compara
Wound healing involved in inflammatory responsedefinition[GO:0002246] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
ECM-receptor interaction  hsa04512+960  
Hematopoietic cell lineage  hsa04640+960  
Shigellosis  hsa05131+960  
According to Reactome, this protein belongs to the following pathways:
Cell surface interactions at the vascular wall  REACT_12051  
Degradation of the extracellular matrix  REACT_118572  
Hyaluronan uptake and degradation  REACT_120996  
Integrin cell surface interactions  REACT_13552  
Interferon gamma signaling  REACT_25078  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Molecular function 
Blood group antigen  definition   [KW-0095]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD44
GenomeRNAi: 960
PRO: PR:P16070