H2AFX - Histone H2AX - human protein (Function)
 
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Protein
Gene
References

 
H2AFX »  Histone H2AX  (H2a/x)
 
Protein also known as:  Histone H2A.X.
Gene name:  H2AFX
Family name: Histone H2A
Entry whose protein(s) existence is based on evidence at protein level
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1 210 1
GENE REF ISO

Function

 show evidences
Overview 
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.  
4
  • CuratedUniProtKB
GO molecular function 
Damaged DNA bindingdefinition[GO:0003684] silver  
  • IEAOrtholog Compara
DNA bindingdefinition[GO:0003677]  
1
  • NASUniProtKB
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Histone bindingdefinition[GO:0042393]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
18
  • IPIIntAct
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAInterPro 2 GO
GO biological process 
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IDABHF-UCL
DNA damage checkpointdefinition[GO:0000077]  
1
  • IDAUniProtKB
Double-strand break repairdefinition[GO:0006302]  
1
  • NASUniProtKB
Meiosisdefinition[GO:0007126]  
  • IEAUniProtKB KW
Nucleosome assemblydefinition[GO:0006334]  
1
  • NASUniProtKB
Positive regulation of DNA repairdefinition[GO:0045739]  
1
  • NASUniProtKB
Response to ionizing radiationdefinition[GO:0010212]  
1
  • NASUniProtKB
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Systemic lupus erythematosus  hsa05322+3014  
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Cellular responses to stress  REACT_120956  
Disease  REACT_116125  
DNA Repair  REACT_216  
Meiosis  REACT_111183  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
DNA damage  definition   [KW-0227]
DNA recombination  definition   [KW-0233]
DNA repair  definition   [KW-0234]
Meiosis  definition   [KW-0469]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: H2AFX
GenomeRNAi: 3014
PRO: PR:P16104