H2AFX - Histone H2AX - human protein (Function)
 
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Protein
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References

 
H2AFX »  Histone H2AX  (H2a/x)
 
Protein also known as:  Histone H2A.X.
Gene name:  H2AFX
Family name: Histone H2A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 337 1
GENE REF ISO

Function

 show evidences
Overview 
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.  
4
  • CuratedUniProtKB
GO molecular function 
Damaged DNA bindingdefinition[GO:0003684] silver  
  • IEAOrtholog Compara
DNA bindingdefinition[GO:0003677]  
1
  • NASUniProtKB
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Histone bindingdefinition[GO:0042393]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
18
  • IPIIntAct
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAInterPro 2 GO
GO biological process 
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IDABHF-UCL
DNA damage checkpointdefinition[GO:0000077]  
1
  • IDAUniProtKB
Double-strand break repairdefinition[GO:0006302]  
1
  • NASUniProtKB
Meiotic nuclear divisiondefinition[GO:0007126]  
  • IEAUniProtKB KW
Nucleosome assemblydefinition[GO:0006334]  
1
  • NASUniProtKB
Positive regulation of DNA repairdefinition[GO:0045739]  
1
  • NASUniProtKB
Response to ionizing radiationdefinition[GO:0010212]  
1
  • NASUniProtKB
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Systemic lupus erythematosus  hsa05322+3014  
According to Reactome, this protein belongs to the following pathways:
Amyloids  REACT_75925  
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks  REACT_486  
ATM mediated phosphorylation of repair proteins  REACT_1924  
Condensation of Prophase Chromosomes  REACT_172744  
Deposition of new CENPA-containing nucleosomes at the centromere  REACT_22186  
DNA Damage/Telomere Stress Induced Senescence  REACT_169185  
formation of the beta-catenin:TCF transactivating complex  REACT_200753  
Meiotic recombination  REACT_27271  
Meiotic synapsis  REACT_75792  
MRN complex relocalizes to nuclear foci  REACT_1884  
NoRC negatively regulates rRNA expression  REACT_200856  
Oxidative Stress Induced Senescence  REACT_169436  
Packaging Of Telomere Ends  REACT_7963  
PRC2 methylates histones and DNA  REACT_200808  
Recruitment of repair and signaling proteins to double-strand breaks  REACT_97  
RNA Polymerase I Chain Elongation  REACT_2204  
RNA Polymerase I Promoter Opening  REACT_2232  
Senescence-Associated Secretory Phenotype (SASP)  REACT_169168  
SIRT1 negatively regulates rRNA Expression  REACT_200827  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
DNA damage  definition   [KW-0227]
DNA recombination  definition   [KW-0233]
DNA repair  definition   [KW-0234]
Meiosis  definition   [KW-0469]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: H2AFX
GenomeRNAi: 3014
PRO: PR:P16104