H2AFX - Histone H2AX - human protein (Function)
 
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H2AFX »  Histone H2AX  (H2a/x)
 
Protein also known as:  Histone H2A.X.
Gene name:  H2AFX
Family name: Histone H2A
Entry whose protein(s) existence is based on evidence at protein level
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1 257 1
GENE REF ISO

Function

 show evidences
Overview 
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.  
5
  • UniProtKB
GO molecular function 
Damaged DNA bindingdefinition[GO:0003684] silver  
1
  • Ortholog Compara
DNA bindingdefinition[GO:0003677]  
2
  • UniProtKB
  • RefGenome
Enzyme bindingdefinition[GO:0019899]  
1
  • UniProtKB
Histone bindingdefinition[GO:0042393]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
20
  • IntAct
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982] silver  
1
  • InterPro 2 GO
GO biological process 
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • BHF-UCL
Cellular response to gamma radiationdefinition[GO:0071480] silver  
1
  • Ortholog Compara
Cellular senescencedefinition[GO:0090398] silver  
1
  • Ortholog Compara
Cerebral cortex developmentdefinition[GO:0021987] silver  
1
  • Ortholog Compara
Chromatin organizationdefinition[GO:0006325]  
1
  • RefGenome
Chromatin silencingdefinition[GO:0006342]  
1
  • RefGenome
DNA damage checkpointdefinition[GO:0000077]  
1
  • UniProtKB
Double-strand break repairdefinition[GO:0006302]  
1
  • UniProtKB
Meiotic cell cycledefinition[GO:0051321]  
1
  • UniProtKB KW
Nucleosome assemblydefinition[GO:0006334]  
1
  • UniProtKB
Positive regulation of DNA repairdefinition[GO:0045739]  
1
  • UniProtKB
Response to ionizing radiationdefinition[GO:0010212]  
1
  • UniProtKB
Spermatogenesisdefinition[GO:0007283] silver  
1
  • Ortholog Compara
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Systemic lupus erythematosus  hsa05322+3014  
According to Reactome, this protein belongs to the following pathways:
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3  R-HSA-5625886  
Amyloid formation  R-HSA-977225  
Condensation of Prophase Chromosomes  R-HSA-2299718  
Deposition of new CENPA-containing nucleosomes at the centromere  R-HSA-606279  
DNA Damage/Telomere Stress Induced Senescence  R-HSA-2559586  
DNA methylation  R-HSA-5334118  
Formation of the beta-catenin:TCF transactivating complex  R-HSA-201722  
G2/M DNA damage checkpoint  R-HSA-69473  
Meiotic recombination  R-HSA-912446  
Meiotic synapsis  R-HSA-1221632  
Nonhomologous End-Joining (NHEJ)  R-HSA-5693571  
NoRC negatively regulates rRNA expression  R-HSA-427413  
Oxidative Stress Induced Senescence  R-HSA-2559580  
Packaging Of Telomere Ends  R-HSA-171306  
PRC2 methylates histones and DNA  R-HSA-212300  
Processing of DNA double-strand break ends  R-HSA-5693607  
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks  R-HSA-5693565  
RMTs methylate histone arginines  R-HSA-3214858  
RNA Polymerase I Chain Elongation  R-HSA-73777  
RNA Polymerase I Promoter Opening  R-HSA-73728  
Senescence-Associated Secretory Phenotype (SASP)  R-HSA-2559582  
SIRT1 negatively regulates rRNA Expression  R-HSA-427359  
Transcriptional regulation by small RNAs  R-HSA-5578749  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
DNA damage  definition   [KW-0227]
DNA recombination  definition   [KW-0233]
DNA repair  definition   [KW-0234]
Host-virus interaction  definition   [KW-0945]
Meiosis  definition   [KW-0469]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: H2AFX
GenomeRNAi: 3014
PRO: PR:P16104