SELP - P-selectin - human protein (Function)
 
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SELP »  P-selectin
 
Protein also known as:  Platelet activation dependent granule-external membrane protein (PADGEM); CD antigen CD62P.
Gene name:  SELP
Family name: Selectin/LECAM
Entry whose protein(s) existence is based on evidence at protein level
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1 237 1
GENE REF ISO

Function

 show evidences
Overview 
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.  
1
  • CuratedUniProtKB
GO molecular function 
Calcium-dependent protein bindingdefinition[GO:0048306] silver  
  • IEAOrtholog Compara
Fucose bindingdefinition[GO:0042806]  
1
  • IDABHF-UCL
Glycoprotein bindingdefinition[GO:0001948] silver  
  • IEAOrtholog Compara
Glycosphingolipid bindingdefinition[GO:0043208]  
1
  • TASBHF-UCL
Heparin bindingdefinition[GO:0008201]  
1
  • IDABHF-UCL
Lipopolysaccharide bindingdefinition[GO:0001530]  
1
  • IMPBHF-UCL
Oligosaccharide bindingdefinition[GO:0070492]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
Sialic acid bindingdefinition[GO:0033691]  
1
  • IDABHF-UCL
GO biological process 
Cell adhesiondefinition[GO:0007155]  
1
  • TASPINC
Defense response to Gram-negative bacteriumdefinition[GO:0050829]  
1
  • ICBHF-UCL
Heterophilic cell-cell adhesiondefinition[GO:0007157] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Leukocyte cell-cell adhesiondefinition[GO:0007159]  
1
  • IDABHF-UCL
Leukocyte tethering or rollingdefinition[GO:0050901] silver  
  • IEAOrtholog Compara
Positive regulation of leukocyte migrationdefinition[GO:0002687] silver  
  • IEAOrtholog Compara
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
1
  • IDAUniProtKB
Positive regulation of platelet activationdefinition[GO:0010572]  
1
  • ISSBHF-UCL
Regulation of integrin activationdefinition[GO:0033623]  
1
  • IMPUniProtKB
Response to lipopolysaccharidedefinition[GO:0032496]  
1
  • ICBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell adhesion molecules (CAMs)  hsa04514+6403  
Malaria  hsa05144+6403  
Staphylococcus aureus infection  hsa05150+6403  
According to Reactome, this protein belongs to the following pathway:
Cell surface interactions at the vascular wall  REACT_12051  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: P-selectin
GenomeRNAi: 6403
PRO: PR:P16109