ACAN - Aggrecan core protein - human protein (Function)
 
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ACAN »  Aggrecan core protein
 
Protein also known as:  Chondroitin sulfate proteoglycan core protein 1 (Chondroitin sulfate proteoglycan 1). Cleaved into:  Aggrecan core protein 2.
Gene name:  ACAN
Entry whose protein(s) existence is based on evidence at protein level
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1 65 3
GENE REF ISO

Function

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Overview 
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.  
  • CuratedUniProtKB
GO molecular function 
Carbohydrate bindingdefinition[GO:0030246] silver  
  • IEAInterPro 2 GO
Extracellular matrix structural constituentdefinition[GO:0005201]  
1
  • TASUniProtKB
Hyaluronic acid bindingdefinition[GO:0005540] silver  
  • IEAInterPro 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Cell adhesiondefinition[GO:0007155] silver  
  • IEAInterPro 2 GO
Proteolysisdefinition[GO:0006508]  
1
  • NASUniProtKB
Skeletal system developmentdefinition[GO:0001501]  
1
  • NASUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Extracellular matrix organization  REACT_118779  
Metabolism  REACT_111217  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links