ACAN - Aggrecan core protein - human protein (Function)
 
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ACAN »  Aggrecan core protein
 
Protein also known as:  Chondroitin sulfate proteoglycan core protein 1 (Chondroitin sulfate proteoglycan 1). Cleaved into:  Aggrecan core protein 2.
Gene name:  ACAN
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.  
1
  • UniProtKB
GO molecular function 
Carbohydrate bindingdefinition[GO:0030246]  
1
  • UniProtKB KW
Extracellular matrix structural constituentdefinition[GO:0005201]  
1
  • UniProtKB
Hyaluronic acid bindingdefinition[GO:0005540] silver  
1
  • InterPro 2 GO
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
GO biological process 
Cell adhesiondefinition[GO:0007155] silver  
1
  • InterPro 2 GO
Proteolysisdefinition[GO:0006508]  
1
  • UniProtKB
Skeletal system developmentdefinition[GO:0001501]  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)  REACT_267635  
Defective CHST6 causes MCDC1  REACT_267713  
Degradation of the extracellular matrix  REACT_118572  
ECM proteoglycans  REACT_163906  
Keratan sulfate biosynthesis  REACT_121120  
Keratan sulfate degradation  REACT_121313  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links