ACADS - Short-chain specific acyl-CoA dehydrogenase, mitochondrial - human protein (Function)
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ACADS »  Short-chain specific acyl-CoA dehydrogenase, mitochondrial   [ EC ]  (SCAD)
Protein also known as:  Butyryl-CoA dehydrogenase.
Gene name:  ACADS
Family name: Acyl-CoA dehydrogenase
Entry whose protein(s) existence is based on evidence at protein level
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1 38 1


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GO molecular function 
Butyryl-CoA dehydrogenase activitydefinition[GO:0004085]  
  • IEAEC 2 GO
Fatty-acyl-CoA bindingdefinition[GO:0000062] silver  
  • IEAOrtholog Compara
Flavin adenine dinucleotide bindingdefinition[GO:0050660] silver  
  • IEAInterPro 2 GO
GO biological process 
Butyrate catabolic processdefinition[GO:0046359] silver  
  • IEAOrtholog Compara
Fatty acid beta-oxidation using acyl-CoA dehydrogenasedefinition[GO:0033539] silver  
  • IEAOrtholog Compara
Protein homotetramerizationdefinition[GO:0051289] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to starvationdefinition[GO:0042594] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC Butanoyl-CoA + electron-transfer flavoprotein 2-butenoyl-CoA + reduced electron-transfer flavoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
  • CuratedUniProtKB
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Butanoate metabolism  hsa00650+35  
Fatty acid metabolism  hsa00071+35  
Metabolic pathways  hsa01100+35  
Valine, leucine and isoleucine degradation  hsa00280+35  
According to Reactome, this protein belongs to the following pathways:
Beta oxidation of butanoyl-CoA to acetyl-CoA  REACT_419  
Beta oxidation of hexanoyl-CoA to butanoyl-CoA  REACT_1887  
More information is available from:
A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.  
  • CuratedUniProtKB


Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

Enzyme and pathway databases
SABIO-RK: P16219
GenomeRNAi: 35
PRO: PR:P16219