CREB1 - Cyclic AMP-responsive element-binding protein 1 - human protein (Function)
 
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CREB1 »  Cyclic AMP-responsive element-binding protein 1  (CREB-1)
 
Gene name:  CREB1
Family name: bZIP
Entry whose protein(s) existence is based on evidence at protein level
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1 374 3
GENE REF ISO

Function

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Overview 
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.  
  • CuratedUniProtKB
GO molecular function 
cAMP response element bindingdefinition[GO:0035497]  
1
  • IDABHF-UCL
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
12
  • IPIIntAct
  • IPIUniProtKB
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • IPIBHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • IDANTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
  • ICGO curators
RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980]  
1
  • IDABHF-UCL
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705]  
1
  • IDABHF-UCL
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001190]  
1
  • IDABHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDAMGI
Transcription cofactor activitydefinition[GO:0003712]  
1
  • TASPINC
GO biological process 
Circadian rhythmdefinition[GO:0007623]  
  • ISSOrtholog Curator
Lactationdefinition[GO:0007595] silver  
  • IEAOrtholog Compara
Lung saccule developmentdefinition[GO:0060430] silver  
  • IEAOrtholog Compara
Negative regulation of transcription by competitive promoter bindingdefinition[GO:0010944]  
1
  • IDABHF-UCL
Pituitary gland developmentdefinition[GO:0021983] silver  
  • IEAOrtholog Compara
Positive regulation of fat cell differentiationdefinition[GO:0045600]  
  • ISSOrtholog Curator
Positive regulation of hormone secretiondefinition[GO:0046887] silver  
  • IEAOrtholog Compara
Positive regulation of lipid biosynthetic processdefinition[GO:0046889]  
  • ISSOrtholog Curator
Positive regulation of multicellular organism growthdefinition[GO:0040018] silver  
  • IEAOrtholog Compara
Positive regulation of osteoclast differentiationdefinition[GO:0045672] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
3
  • IDABHF-UCL
  • IDAMGI
  • IDANTNU_SB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAMGI
Protein stabilizationdefinition[GO:0050821]  
  • ISSOrtholog Curator
Regulation of cell sizedefinition[GO:0008361] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to glucagondefinition[GO:0033762]  
  • ISSOrtholog Curator
Response to organic substancedefinition[GO:0010033]  
1
  • IDAMGI
Secretory granule organizationdefinition[GO:0033363] silver  
  • IEAOrtholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • IDAGOC
Type I pneumocyte differentiationdefinition[GO:0060509] silver  
  • IEAOrtholog Compara
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Antigen processing and presentation  hsa04612+1385  
Cholinergic synapse  hsa04725+1385  
Dopaminergic synapse  hsa04728+1385  
HTLV-I infection  hsa05166+1385  
Huntington's disease  hsa05016+1385  
Melanogenesis  hsa04916+1385  
Osteoclast differentiation  hsa04380+1385  
Prostate cancer  hsa05215+1385  
Tuberculosis  hsa05152+1385  
Vasopressin-regulated water reabsorption  hsa04962+1385  
According to Reactome, this protein belongs to the following pathways:
AKT phosphorylates targets in the nucleus  REACT_12442  
CaMK IV-mediated phosphorylation of CREB  REACT_15502  
Circadian Clock  REACT_24941  
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
CREB phosphorylation  REACT_12524  
CREB phosphorylation through the activation of Adenylate Cyclase  REACT_20625  
CREB phosphorylation through the activation of CaMKII  REACT_20642  
CREB phosphorylation through the activation of CaMKK  REACT_20661  
CREB phosphorylation through the activation of Ras  REACT_20568  
Gastrin-CREB signalling pathway via PKC and MAPK  REACT_120966  
NCAM signaling for neurite out-growth  REACT_18334  
NOTCH2 intracellular domain regulates transcription  REACT_163910  
PKA-mediated phosphorylation of CREB  REACT_15497  
Transcriptional activation of mitochondrial biogenesis  REACT_200608  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Differentiation  definition   [KW-0221]
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CREB1
GenomeRNAi: 1385
PRO: PR:P16220