PECAM1 - Platelet endothelial cell adhesion molecule - human protein (Function)
 
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PECAM1 »  Platelet endothelial cell adhesion molecule  (PECAM-1)
 
Protein also known as:  EndoCAM; CD antigen CD31.
Gene name:  PECAM1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment).  
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  • CuratedUniProtKB
Isoform  Delta15   Is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).  
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  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
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  • IPIUniProtKB
  • IPIIntAct
GO biological process 
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Cell recognitiondefinition[GO:0008037]  
1
  • TASPINC
Diapedesisdefinition[GO:0050904]  
1
  • IDAUniProtKB
Glomerular endothelium developmentdefinition[GO:0072011]  
1
  • IEPUniProtKB
Phagocytosisdefinition[GO:0006909]  
1
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165]  
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  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell adhesion molecules (CAMs)  hsa04514+5175  
Leukocyte transendothelial migration  hsa04670+5175  
Malaria  hsa05144+5175  
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_118779  
Hemostasis  REACT_604  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Phagocytosis  definition   [KW-0581]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD31
GenomeRNAi: 5175
PRO: PR:P16284