NCK1 - Cytoplasmic protein NCK1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
NCK1 »  Cytoplasmic protein NCK1
 
Protein also known as:  SH2/SH3 adaptor protein NCK-alpha.
Gene name:  NCK1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 227 2
GENE REF ISO

Function

 show evidences
Overview 
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.  
7
  • UniProtKB
GO molecular function 
Cytoskeletal adaptor activitydefinition[GO:0008093]  
1
  • UniProtKB
Eukaryotic initiation factor eIF2 bindingdefinition[GO:0071074]  
1
  • ParkinsonsUK-UCL
Protein bindingdefinition[GO:0005515]  
27
  • IntAct
  • UniProtKB
Protein binding, bridgingdefinition[GO:0030674]  
1
  • ParkinsonsUK-UCL
Protein domain specific bindingdefinition[GO:0019904] silver  
1
  • Ortholog Compara
Protein kinase inhibitor activitydefinition[GO:0004860]  
1
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • UniProtKB
Receptor signaling complex scaffold activitydefinition[GO:0030159]  
1
  • UniProtKB
Receptor tyrosine kinase bindingdefinition[GO:0030971]  
1
  • UniProtKB
SH3/SH2 adaptor activitydefinition[GO:0005070]  
1
  • ParkinsonsUK-UCL
GO biological process 
Actin filament organizationdefinition[GO:0007015] silver  
1
  • Ortholog Compara
Lamellipodium assemblydefinition[GO:0030032] silver  
1
  • Ortholog Compara
Negative regulation of cell deathdefinition[GO:0060548]  
1
  • UniProtKB
Negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylationdefinition[GO:1903912]  
2
  • ParkinsonsUK-UCL
Negative regulation of peptidyl-serine phosphorylationdefinition[GO:0033137]  
2
  • ParkinsonsUK-UCL
Negative regulation of PERK-mediated unfolded protein responsedefinition[GO:1903898]  
1
  • ParkinsonsUK-UCL
Negative regulation of protein kinase activitydefinition[GO:0006469]  
1
  • GOC
Negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stressdefinition[GO:1990441]  
1
  • ParkinsonsUK-UCL
Peptidyl-serine dephosphorylationdefinition[GO:0070262]  
1
  • ParkinsonsUK-UCL
Positive regulation of actin filament polymerizationdefinition[GO:0030838]  
1
  • UniProtKB
Positive regulation of cap-dependent translational initiationdefinition[GO:1903676]  
1
  • ParkinsonsUK-UCL
Positive regulation of cap-independent translational initiationdefinition[GO:1903679]  
1
  • ParkinsonsUK-UCL
Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwaydefinition[GO:1902237]  
1
  • ParkinsonsUK-UCL
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • UniProtKB
Positive regulation of translation in response to endoplasmic reticulum stressdefinition[GO:0036493]  
1
  • ParkinsonsUK-UCL
Response to other organismdefinition[GO:0051707] silver  
1
  • Ortholog Compara
Signal complex assemblydefinition[GO:0007172]  
1
  • UniProtKB
Substrate-dependent cell migration, cell extensiondefinition[GO:0006930] silver  
1
  • Ortholog Compara
T cell activationdefinition[GO:0042110]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+4690  
ErbB signaling pathway  hsa04012+4690  
Pathogenic Escherichia coli infection  hsa05130+4690  
T cell receptor signaling pathway  hsa04660+4690  
According to Reactome, this protein belongs to the following pathways:
Activation of Rac  REACT_19226  
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  REACT_118700  
DCC mediated attractive signaling  REACT_22351  
Downstream signal transduction  REACT_17025  
Generation of second messenger molecules  REACT_12623  
Nephrin interactions  REACT_23832  
Regulation of actin dynamics for phagocytic cup formation  REACT_160086  
VEGFA-VEGFR2 Pathway  REACT_264464  
 

Keywords

Biological process 
Translation regulation  definition   [KW-0810]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NCK1
GenomeRNAi: 4690
PRO: PR:P16333