NCK1 - Cytoplasmic protein NCK1 - human protein (Function)
 
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NCK1 »  Cytoplasmic protein NCK1
 
Protein also known as:  SH2/SH3 adaptor protein NCK-alpha.
Gene name:  NCK1
Entry whose protein(s) existence is based on evidence at protein level
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1 202 2
GENE REF ISO

Function

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Overview 
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.  
6
  • CuratedUniProtKB
GO molecular function 
Cytoskeletal adaptor activitydefinition[GO:0008093]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
23
  • IPIIntAct
  • IPIUniProtKB
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
Protein kinase inhibitor activitydefinition[GO:0004860]  
1
  • IDAUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
Receptor signaling complex scaffold activitydefinition[GO:0030159]  
1
  • NASUniProtKB
Receptor tyrosine kinase bindingdefinition[GO:0030971]  
1
  • IPIUniProtKB
GO biological process 
Actin filament organizationdefinition[GO:0007015] silver  
  • IEAOrtholog Compara
Cell migrationdefinition[GO:0016477] silver  
  • IEAOrtholog Compara
Lamellipodium assemblydefinition[GO:0030032] silver  
  • IEAOrtholog Compara
Negative regulation of cell deathdefinition[GO:0060548]  
1
  • IDAUniProtKB
Negative regulation of protein kinase activitydefinition[GO:0006469]  
1
  • IDAGOC
Positive regulation of actin filament polymerizationdefinition[GO:0030838]  
1
  • IMPUniProtKB
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • IMPUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Regulation of translationdefinition[GO:0006417]  
  • IEAUniProtKB KW
Response to other organismdefinition[GO:0051707] silver  
  • IEAOrtholog Compara
Signal complex assemblydefinition[GO:0007172]  
1
  • NASUniProtKB
T cell activationdefinition[GO:0042110]  
1
  • IMPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+4690  
ErbB signaling pathway  hsa04012+4690  
Pathogenic Escherichia coli infection  hsa05130+4690  
T cell receptor signaling pathway  hsa04660+4690  
According to Reactome, this protein belongs to the following pathways:
Activation of Rac  REACT_19226  
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  REACT_118700  
DCC mediated attractive signaling  REACT_22351  
Downstream signal transduction  REACT_17025  
Generation of second messenger molecules  REACT_12623  
Nephrin interactions  REACT_23832  
Regulation of actin dynamics for phagocytic cup formation  REACT_160086  
 

Keywords

Biological process 
Translation regulation  definition   [KW-0810]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NCK1
GenomeRNAi: 4690
PRO: PR:P16333