CTLA4 - Cytotoxic T-lymphocyte protein 4 - human protein (Function)
 
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CTLA4 »  Cytotoxic T-lymphocyte protein 4
 
Protein also known as:  Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4); CD antigen CD152.
Gene name:  CTLA4
Entry whose protein(s) existence is based on evidence at protein level
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1 457 5
GENE REF ISO

Function

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Overview 
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
GO biological process 
B cell receptor signaling pathwaydefinition[GO:0050853]  
1
  • IMPUniProtKB
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IMPUniProtKB
Immune responsedefinition[GO:0006955] silver  
  • IEAInterPro 2 GO
Negative regulation of B cell proliferationdefinition[GO:0030889]  
1
  • IMPUniProtKB
Negative regulation of immune responsedefinition[GO:0050777] silver  
  • IEAOrtholog Compara
Negative regulation of regulatory T cell differentiationdefinition[GO:0045590]  
1
  • IDABHF-UCL
Negative regulation of T cell proliferationdefinition[GO:0042130] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • IMPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Autoimmune thyroid disease  hsa05320+1493  
Cell adhesion molecules (CAMs)  hsa04514+1493  
Rheumatoid arthritis  hsa05323+1493  
T cell receptor signaling pathway  hsa04660+1493  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
Immunity  definition   [KW-0391]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CTLA-4
GenomeRNAi: 1493
PRO: PR:P16410