POR - NADPH--cytochrome P450 reductase - human protein (Function)
 
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POR »  NADPH--cytochrome P450 reductase   [ EC 1.6.2.4 ]  (CPR)
 
Gene name:  POR
Family name: In the C-terminal section Flavoprotein pyridine nucleotide cytochrome reductase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.  
1
  • UniProtKB
GO molecular function 
Cytochrome-b5 reductase activity, acting on NAD(P)Hdefinition[GO:0004128] silver  
1
  • Ortholog Compara
Electron carrier activitydefinition[GO:0009055] silver  
1
  • Ortholog Compara
Enzyme bindingdefinition[GO:0019899] silver  
1
  • Ortholog Compara
Flavin adenine dinucleotide bindingdefinition[GO:0050660] silver  
1
  • Ortholog Compara
FMN bindingdefinition[GO:0010181] silver  
1
  • InterPro 2 GO
Hydrolase activitydefinition[GO:0016787] silver  
1
  • Ortholog Compara
Iron ion bindingdefinition[GO:0005506] silver  
1
  • InterPro 2 GO
Iron-cytochrome-c reductase activitydefinition[GO:0047726] silver  
1
  • Ortholog Compara
NADP bindingdefinition[GO:0050661] silver  
1
  • Ortholog Compara
NADPH-hemoprotein reductase activitydefinition[GO:0003958]  
3
  • BHF-UCL
  • UniProtKB
Nitric oxide dioxygenase activitydefinition[GO:0008941] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
Carnitine metabolic processdefinition[GO:0009437] silver  
1
  • Ortholog Compara
Cellular organofluorine metabolic processdefinition[GO:0090346]  
1
  • BHF-UCL
Cellular response to follicle-stimulating hormone stimulusdefinition[GO:0071372] silver  
1
  • Ortholog Compara
Cellular response to peptide hormone stimulusdefinition[GO:0071375] silver  
1
  • Ortholog Compara
Demethylationdefinition[GO:0070988] silver  
1
  • Ortholog Compara
Fatty acid oxidationdefinition[GO:0019395] silver  
1
  • Ortholog Compara
Flavonoid metabolic processdefinition[GO:0009812] silver  
1
  • Ortholog Compara
Internal peptidyl-lysine acetylationdefinition[GO:0018393] silver  
1
  • Ortholog Compara
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154] silver  
1
  • Ortholog Compara
Negative regulation of lipase activitydefinition[GO:0060192] silver  
1
  • Ortholog Compara
Nitrate catabolic processdefinition[GO:0043602] silver  
1
  • Ortholog Compara
Nitric oxide catabolic processdefinition[GO:0046210] silver  
1
  • Ortholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
2
  • BHF-UCL
  • UniProtKB
Positive regulation of cholesterol biosynthetic processdefinition[GO:0045542] silver  
1
  • Ortholog Compara
Positive regulation of chondrocyte differentiationdefinition[GO:0032332] silver  
1
  • Ortholog Compara
Positive regulation of monooxygenase activitydefinition[GO:0032770]  
1
  • BHF-UCL
Positive regulation of smoothened signaling pathwaydefinition[GO:0045880] silver  
1
  • Ortholog Compara
Positive regulation of steroid hormone biosynthetic processdefinition[GO:0090031] silver  
1
  • Ortholog Compara
Regulation of growth plate cartilage chondrocyte proliferationdefinition[GO:0003420] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to nutrientdefinition[GO:0007584] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.6.2.4: NADPH + n oxidized hemoprotein NADP(+) + n reduced hemoprotein.  
1
  • UniProtKB
It requires the following cofactors
 FAD  
1
  • UniProtKB
 FMN  
1
  • UniProtKB
Pathways 
 
More information is available from:
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P16435
Other
GeneWiki: Cytochrome_P450_reductase
GenomeRNAi: 5447
PRO: PR:P16435