DPEP1 - Dipeptidase 1 - human protein (Function)
 
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Protein
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References

 
DPEP1 »  Dipeptidase 1   [ EC 3.4.13.19 ]
 
Protein also known as:  Microsomal dipeptidase.
Gene name:  DPEP1
Family name: Peptidase M19
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 32 1
GENE REF ISO

Function

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Overview 
Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity.  
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase inhibitor activity involved in apoptotic processdefinition[GO:0043027]  
1
  • IMPUniProtKB
Dipeptidyl-peptidase activitydefinition[GO:0008239] silver  
  • IEAInterPro 2 GO
GPI anchor bindingdefinition[GO:0034235]  
  • ISSOrtholog Curator
Metallodipeptidase activitydefinition[GO:0070573]  
2
  • IDAUniProtKB
Metalloexopeptidase activitydefinition[GO:0008235]  
1
  • TASUniProtKB
Modified amino acid bindingdefinition[GO:0072341]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Zinc ion bindingdefinition[GO:0008270]  
1
  • IDAUniProtKB
GO biological process 
Antibiotic metabolic processdefinition[GO:0016999]  
1
  • IDAUniProtKB
Cellular lactam catabolic processdefinition[GO:0072340]  
1
  • TASUniProtKB
Cellular response to calcium iondefinition[GO:0071277]  
  • ISSOrtholog Curator
Cellular response to drugdefinition[GO:0035690]  
1
  • IDAUniProtKB
Cellular response to nitric oxidedefinition[GO:0071732]  
  • ISSOrtholog Curator
Glutathione metabolic processdefinition[GO:0006749]  
1
  • TASUniProtKB
Homocysteine metabolic processdefinition[GO:0050667]  
1
  • IDAUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IMPUniProtKB
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • IMPUniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154]  
1
  • IMPUniProtKB
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.13.19: Hydrolysis of dipeptides.  
  • CuratedUniProtKB
It requires the following cofactor
Zinc.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by L-penicillamine (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Molecular function 
Dipeptidase  definition   [KW-0224]
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P16444
Other
GeneWiki: Dipeptidase_1
GenomeRNAi: 1800
PRO: PR:P16444