EPB42 - Erythrocyte membrane protein band 4.2 - human protein (Function)
 
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EPB42 »  Erythrocyte membrane protein band 4.2  (P4.2)
 
Gene name:  EPB42
Entry whose protein(s) existence is based on evidence at protein level
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1 41 2
GENE REF ISO

Function

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Overview 
Probably plays an important role in the regulation of erythrocyte shape and mechanical properties.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein-glutamine gamma-glutamyltransferase activitydefinition[GO:0003810] silver  
  • IEAInterPro 2 GO
Structural constituent of cytoskeletondefinition[GO:0005200]  
1
  • TASPINC
GO biological process 
Cell morphogenesisdefinition[GO:0000902] silver  
  • IEAOrtholog Compara
Erythrocyte maturationdefinition[GO:0043249]  
  • IEAUniProtKB KW
Hemoglobin metabolic processdefinition[GO:0020027] silver  
  • IEAOrtholog Compara
Iron ion homeostasisdefinition[GO:0055072] silver  
  • IEAOrtholog Compara
Peptide cross-linkingdefinition[GO:0018149] silver  
  • IEAInterPro 2 GO
Regulation of cell shapedefinition[GO:0008360]  
  • IEAUniProtKB KW
Spleen developmentdefinition[GO:0048536] silver  
  • IEAOrtholog Compara
Note 
The substitution of an Ala for a Cys in the active site may be responsible for the lack of transglutaminase activity of band 4.2.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Cell shape  definition   [KW-0133]
Erythrocyte maturation  definition   [KW-0265]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Protein_4.2
GenomeRNAi: 2038
PRO: PR:P16452