TSHR - Thyrotropin receptor - human protein (Function)
 
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TSHR »  Thyrotropin receptor
 
Protein also known as:  Thyroid-stimulating hormone receptor (TSH-R).
Gene name:  TSHR
Entry whose protein(s) existence is based on evidence at protein level
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1 286 3
GENE REF ISO

Function

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Overview 
Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).  
2
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Thyroid-stimulating hormone receptor activitydefinition[GO:0004996] silver  
1
  • Ortholog Compara
GO biological process 
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189] silver  
1
  • Ortholog Compara
Adult locomotory behaviordefinition[GO:0008344] silver  
1
  • Ortholog Compara
B cell differentiationdefinition[GO:0030183] silver  
1
  • Ortholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • PINC
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerdefinition[GO:0007187]  
1
  • PINC
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • PINC
Positive regulation of multicellular organism growthdefinition[GO:0040018] silver  
1
  • Ortholog Compara
Regulation of locomotiondefinition[GO:0040012] silver  
1
  • Ortholog Compara
Thyroid-stimulating hormone signaling pathwaydefinition[GO:0038194]  
3
  • GOC
  • InterPro 2 GO
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Autoimmune thyroid disease  hsa05320+7253  
Neuroactive ligand-receptor interaction  hsa04080+7253  
According to Reactome, this protein belongs to the following pathways:
G alpha (s) signalling events  REACT_19327  
Hormone ligand-binding receptors  REACT_16942  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Thyrotropin_receptor
GenomeRNAi: 7253
PRO: PR:P16473
Chemistry
GuidetoPHARMACOLOGY: 255