GNB3 - Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 - human protein (Function)
 
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GNB3 »  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
 
Protein also known as:  Transducin beta chain 3.
Gene name:  GNB3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.  
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  • UniProtKB
GO molecular function 
GTPase activitydefinition[GO:0003924]  
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  • PINC
GTPase bindingdefinition[GO:0051020]  
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  • UniProtKB
Protein bindingdefinition[GO:0005515]  
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  • IntAct
Signal transducer activitydefinition[GO:0004871]  
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  • UniProtKB KW
GO biological process 
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
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  • PINC
Regulation of blood pressuredefinition[GO:0008217]  
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  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+2784  
Cholinergic synapse  hsa04725+2784  
Dopaminergic synapse  hsa04728+2784  
GABAergic synapse  hsa04727+2784  
Glutamatergic synapse  hsa04724+2784  
Taste transduction  hsa04742+2784  
According to Reactome, this protein belongs to the following pathways:
Activation of G protein gated Potassium channels  R-HSA-1296041  
ADP signalling through P2Y purinoceptor 1  R-HSA-418592  
ADP signalling through P2Y purinoceptor 12  R-HSA-392170  
Adrenaline,noradrenaline inhibits insulin secretion  R-HSA-400042  
Ca2+ pathway  R-HSA-4086398  
G alpha (12/13) signalling events  R-HSA-416482  
G alpha (i) signalling events  R-HSA-418594  
G alpha (q) signalling events  R-HSA-416476  
G alpha (s) signalling events  R-HSA-418555  
G alpha (z) signalling events  R-HSA-418597  
G beta:gamma signalling through PI3Kgamma  R-HSA-392451  
G beta:gamma signalling through PLC beta  R-HSA-418217  
G-protein activation  R-HSA-202040  
Glucagon signaling in metabolic regulation  R-HSA-163359  
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  R-HSA-381676  
Glucagon-type ligand receptors  R-HSA-420092  
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits  R-HSA-997272  
Presynaptic function of Kainate receptors  R-HSA-500657  
Prostacyclin signalling through prostacyclin receptor  R-HSA-392851  
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)  R-HSA-381771  
Thrombin signalling through proteinase activated receptors (PARs)  R-HSA-456926  
Thromboxane signalling through TP receptor  R-HSA-428930  
Vasopressin regulates renal water homeostasis via Aquaporins  R-HSA-432040  
 

Keywords

Molecular function 
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GNB3
GenomeRNAi: 2784
PRO: PR:P16520