GNB3 - Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 - human protein (Function)
 
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GNB3 »  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
 
Protein also known as:  Transducin beta chain 3.
Gene name:  GNB3
Entry whose protein(s) existence is based on evidence at protein level
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1 135 1
GENE REF ISO

Function

 show evidences
Overview 
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.  
  • CuratedUniProtKB
GO molecular function 
GTPase activitydefinition[GO:0003924]  
1
  • TASPINC
GTPase bindingdefinition[GO:0051020]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Signal transducer activitydefinition[GO:0004871]  
  • IEAUniProtKB KW
GO biological process 
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
GTP catabolic processdefinition[GO:0006184]  
1
  • TASGOC
Regulation of blood pressuredefinition[GO:0008217]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+2784  
Cholinergic synapse  hsa04725+2784  
Dopaminergic synapse  hsa04728+2784  
GABAergic synapse  hsa04727+2784  
Glutamatergic synapse  hsa04724+2784  
Taste transduction  hsa04742+2784  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Metabolism  REACT_111217  
Neuronal System  REACT_13685  
Signal Transduction  REACT_111102  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Molecular function 
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GNB3
GenomeRNAi: 2784
PRO: PR:P16520