GNB3 - Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 - human protein (Function)
 
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GNB3 »  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
 
Protein also known as:  Transducin beta chain 3.
Gene name:  GNB3
Entry whose protein(s) existence is based on evidence at protein level
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1 136 2
GENE REF ISO

Function

 show evidences
Overview 
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.  
  • CuratedUniProtKB
GO molecular function 
GTPase activitydefinition[GO:0003924]  
1
  • TASPINC
GTPase bindingdefinition[GO:0051020]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Signal transducer activitydefinition[GO:0004871]  
  • IEAUniProtKB KW
GO biological process 
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
GTP catabolic processdefinition[GO:0006184]  
1
  • TASGOC
Regulation of blood pressuredefinition[GO:0008217]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+2784  
Cholinergic synapse  hsa04725+2784  
Dopaminergic synapse  hsa04728+2784  
GABAergic synapse  hsa04727+2784  
Glutamatergic synapse  hsa04724+2784  
Taste transduction  hsa04742+2784  
According to Reactome, this protein belongs to the following pathways:
Activation of G protein gated Potassium channels  REACT_75831  
ADP signalling through P2Y purinoceptor 1  REACT_19140  
ADP signalling through P2Y purinoceptor 12  REACT_20653  
Adrenaline,noradrenaline inhibits insulin secretion  REACT_18339  
Ca2+ pathway  REACT_172761  
G alpha (12/13) signalling events  REACT_18407  
G alpha (i) signalling events  REACT_19231  
G alpha (q) signalling events  REACT_18283  
G alpha (s) signalling events  REACT_19327  
G alpha (z) signalling events  REACT_19333  
G beta:gamma signalling through PI3Kgamma  REACT_19290  
G beta:gamma signalling through PLC beta  REACT_19145  
G-protein activation  REACT_15457  
Glucagon signaling in metabolic regulation  REACT_1665  
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  REACT_18274  
Glucagon-type ligand receptors  REACT_18377  
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits  REACT_25004  
Presynaptic function of Kainate receptors  REACT_21254  
Prostacyclin signalling through prostacyclin receptor  REACT_23946  
Regulation of water balance by renal Aquaporins  REACT_24023  
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)  REACT_24019  
Thrombin signalling through proteinase activated receptors (PARs)  REACT_21384  
Thromboxane signalling through TP receptor  REACT_20647  
 

Keywords

Molecular function 
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GNB3
GenomeRNAi: 2784
PRO: PR:P16520