SELE - E-selectin - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
SELE »  E-selectin
 
Protein also known as:  Leukocyte-endothelial cell adhesion molecule 2 (LECAM2); CD antigen CD62E.
Gene name:  SELE
Family name: Selectin/LECAM
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 256 1
GENE REF ISO

Function

 show evidences
Overview 
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.  
1
  • CuratedUniProtKB
GO molecular function 
Oligosaccharide bindingdefinition[GO:0070492]  
1
  • IDABHF-UCL
Phospholipase bindingdefinition[GO:0043274]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Sialic acid bindingdefinition[GO:0033691]  
1
  • IDABHF-UCL
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • IMPBHF-UCL
GO biological process 
Actin filament-based processdefinition[GO:0030029]  
1
  • IDABHF-UCL
Activation of phospholipase C activitydefinition[GO:0007202]  
1
  • IMPBHF-UCL
Calcium-mediated signalingdefinition[GO:0019722]  
1
  • TASBHF-UCL
Heterophilic cell-cell adhesiondefinition[GO:0007157]  
1
  • IMPBHF-UCL
Inflammatory responsedefinition[GO:0006954]  
1
  • TASPINC
Leukocyte cell-cell adhesiondefinition[GO:0007159]  
1
  • IDABHF-UCL
Leukocyte migration involved in inflammatory responsedefinition[GO:0002523]  
1
  • TASBHF-UCL
Leukocyte tethering or rollingdefinition[GO:0050901]  
1
  • IMPBHF-UCL
Positive regulation of leukocyte migrationdefinition[GO:0002687] silver  
  • IEAOrtholog Compara
Positive regulation of receptor internalizationdefinition[GO:0002092]  
1
  • IDABHF-UCL
Regulation of inflammatory responsedefinition[GO:0050727]  
1
  • TASBHF-UCL
Response to interleukin-1definition[GO:0070555]  
1
  • IDABHF-UCL
Response to lipopolysaccharidedefinition[GO:0032496]  
1
  • TASBHF-UCL
Response to tumor necrosis factordefinition[GO:0034612]  
1
  • TASBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
African trypanosomiasis  hsa05143+6401  
Cell adhesion molecules (CAMs)  hsa04514+6401  
Malaria  hsa05144+6401  
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: E-selectin
GenomeRNAi: 6401
PRO: PR:P16581