FER - Tyrosine-protein kinase Fer - human protein (Function)
 
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FER »  Tyrosine-protein kinase Fer   [ EC 2.7.10.2 ]
 
Protein also known as:  Fujinami poultry sarcoma/Feline sarcoma-related protein Fer.
Gene name:  FER
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 146 3
GENE REF ISO

Function

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Overview 
Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.  
11
  • UniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779] silver  
1
  • Ortholog Compara
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Cadherin bindingdefinition[GO:0045296] silver  
1
  • Ortholog Compara
Epidermal growth factor receptor bindingdefinition[GO:0005154]  
1
  • UniProtKB
Gamma-catenin bindingdefinition[GO:0045295] silver  
1
  • Ortholog Compara
Lipid bindingdefinition[GO:0008289]  
1
  • UniProtKB
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Protein kinase bindingdefinition[GO:0019901] silver  
1
  • Ortholog Compara
Protein phosphatase 1 bindingdefinition[GO:0008157] silver  
1
  • Ortholog Compara
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • PINC
Rab GTPase bindingdefinition[GO:0017137] silver  
1
  • Ortholog Compara
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
1
  • Ortholog Curator
Cell adhesiondefinition[GO:0007155]  
1
  • RefGenome
Cell differentiationdefinition[GO:0030154]  
1
  • RefGenome
Cell proliferationdefinition[GO:0008283]  
1
  • UniProtKB
Cell-cell adhesion mediated by cadherindefinition[GO:0044331]  
1
  • Ortholog Curator
Cellular response to insulin stimulusdefinition[GO:0032869]  
1
  • Ortholog Curator
Cellular response to macrophage colony-stimulating factor stimulusdefinition[GO:0036006]  
1
  • UniProtKB
Cellular response to reactive oxygen speciesdefinition[GO:0034614]  
1
  • Ortholog Curator
Chemotaxisdefinition[GO:0006935]  
1
  • RefGenome
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • UniProtKB
Diapedesisdefinition[GO:0050904]  
1
  • Ortholog Curator
Extracellular matrix-cell signalingdefinition[GO:0035426]  
1
  • Ortholog Curator
Fc-epsilon receptor signaling pathwaydefinition[GO:0038095]  
2
  • RefGenome
  • Ortholog Curator
Innate immune responsedefinition[GO:0045087]  
1
  • RefGenome
Insulin receptor signaling pathway via phosphatidylinositol 3-kinasedefinition[GO:0038028]  
1
  • Ortholog Curator
Interleukin-6-mediated signaling pathwaydefinition[GO:0070102]  
1
  • UniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
1
  • PINC
Kit signaling pathwaydefinition[GO:0038109]  
1
  • Ortholog Curator
Microtubule cytoskeleton organizationdefinition[GO:0000226]  
1
  • UniProtKB
Mitotic cell cycledefinition[GO:0000278]  
1
  • UniProtKB
Negative regulation of mast cell activation involved in immune responsedefinition[GO:0033007]  
1
  • Ortholog Curator
Peptidyl-tyrosine autophosphorylationdefinition[GO:0038083]  
1
  • RefGenome
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
2
  • UniProtKB
Platelet-derived growth factor receptor signaling pathwaydefinition[GO:0048008]  
2
  • UniProtKB
  • Ortholog Curator
Positive regulation of actin filament polymerizationdefinition[GO:0030838]  
1
  • UniProtKB
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • UniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • UniProtKB
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • UniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • PINC
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • RefGenome
Regulation of epidermal growth factor receptor signaling pathwaydefinition[GO:0042058]  
1
  • UniProtKB
Regulation of fibroblast migrationdefinition[GO:0010762] silver  
1
  • Ortholog Compara
Regulation of lamellipodium assemblydefinition[GO:0010591]  
1
  • UniProtKB
Regulation of mast cell degranulationdefinition[GO:0043304]  
1
  • RefGenome
Regulation of protein phosphorylationdefinition[GO:0001932]  
1
  • Ortholog Curator
Response to lipopolysaccharidedefinition[GO:0032496]  
1
  • Ortholog Curator
Response to platelet-derived growth factordefinition[GO:0036119]  
1
  • Ortholog Curator
Substrate adhesion-dependent cell spreadingdefinition[GO:0034446]  
1
  • Ortholog Curator
Tyrosine phosphorylation of Stat3 proteindefinition[GO:0042503]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.2: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
4
  • UniProtKB
  • PROSITE-ProRule
It is regulated in the following manner
Activated by phosphatidic acid binding. Activated by hydrogen peroxide (in vitro). Activated by reactive oxygen species (ROS).  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Adherens junction  hsa04520+2241  
According to Reactome, this protein belongs to the following pathway:
Signaling by SCF-KIT  REACT_111040  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: FER_(gene)
GenomeRNAi: 2241
PRO: PR:P16591
Chemistry
GuidetoPHARMACOLOGY: 2022