FER - Tyrosine-protein kinase Fer - human protein (Function)
 
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FER »  Tyrosine-protein kinase Fer   [ EC 2.7.10.2 ]
 
Protein also known as:  Fujinami poultry sarcoma/Feline sarcoma-related protein Fer.
Gene name:  FER
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 53 3
GENE REF ISO

Function

 show evidences
Overview 
Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.  
10
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779] silver  
  • IEAOrtholog Compara
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Cadherin bindingdefinition[GO:0045296] silver  
  • IEAOrtholog Compara
Epidermal growth factor receptor bindingdefinition[GO:0005154]  
1
  • IDAUniProtKB
Gamma-catenin bindingdefinition[GO:0045295] silver  
  • IEAOrtholog Compara
Lipid bindingdefinition[GO:0008289]  
1
  • IDAUniProtKB
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein kinase bindingdefinition[GO:0019901] silver  
  • IEAOrtholog Compara
Protein phosphatase 1 bindingdefinition[GO:0008157] silver  
  • IEAOrtholog Compara
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • TASPINC
Rab GTPase bindingdefinition[GO:0017137] silver  
  • IEAOrtholog Compara
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
  • ISSOrtholog Curator
Cell proliferationdefinition[GO:0008283]  
1
  • IMPUniProtKB
Cell-cell adhesion mediated by cadherindefinition[GO:0044331]  
  • ISSOrtholog Curator
Cellular response to insulin stimulusdefinition[GO:0032869]  
  • ISSOrtholog Curator
Cellular response to macrophage colony-stimulating factor stimulusdefinition[GO:0036006]  
1
  • IMPUniProtKB
Cellular response to reactive oxygen speciesdefinition[GO:0034614]  
  • ISSOrtholog Curator
Chemotaxisdefinition[GO:0006935] silver  
  • IEAOrtholog Compara
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • IMPUniProtKB
Diapedesisdefinition[GO:0050904]  
  • ISSOrtholog Curator
Extracellular matrix-cell signalingdefinition[GO:0035426]  
  • ISSOrtholog Curator
Fc-epsilon receptor signaling pathwaydefinition[GO:0038095]  
  • ISSOrtholog Curator
Insulin receptor signaling pathway via phosphatidylinositol 3-kinasedefinition[GO:0038028]  
  • ISSOrtholog Curator
Interleukin-6-mediated signaling pathwaydefinition[GO:0070102]  
1
  • IMPUniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
1
  • TASPINC
Kit signaling pathwaydefinition[GO:0038109]  
  • ISSOrtholog Curator
Microtubule cytoskeleton organizationdefinition[GO:0000226]  
1
  • IMPUniProtKB
Mitotic cell cycledefinition[GO:0000278]  
1
  • IMPUniProtKB
Negative regulation of mast cell activation involved in immune responsedefinition[GO:0033007]  
  • ISSOrtholog Curator
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
2
  • IDAUniProtKB
Platelet-derived growth factor receptor signaling pathwaydefinition[GO:0048008]  
1
  • TASUniProtKB
  • ISSOrtholog Curator
Positive regulation of actin filament polymerizationdefinition[GO:0030838]  
1
  • IMPUniProtKB
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IMPUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • TASUniProtKB
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IMPUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • TASPINC
Regulation of epidermal growth factor receptor signaling pathwaydefinition[GO:0042058]  
1
  • IMPUniProtKB
Regulation of fibroblast migrationdefinition[GO:0010762] silver  
  • IEAOrtholog Compara
Regulation of lamellipodium assemblydefinition[GO:0010591]  
1
  • IDAUniProtKB
Regulation of protein phosphorylationdefinition[GO:0001932]  
  • ISSOrtholog Curator
Response to lipopolysaccharidedefinition[GO:0032496]  
  • ISSOrtholog Curator
Response to platelet-derived growth factordefinition[GO:0036119]  
  • ISSOrtholog Curator
Substrate adhesion-dependent cell spreadingdefinition[GO:0034446]  
  • ISSOrtholog Curator
Tyrosine phosphorylation of Stat3 proteindefinition[GO:0042503]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.2: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • CuratedUniProtKB
It is regulated in the following manner
Activated by phosphatidic acid binding. Activated by hydrogen peroxide (in vitro). Activated by reactive oxygen species (ROS).  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Adherens junction  hsa04520+2241  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: FER_(gene)
GenomeRNAi: 2241
PRO: PR:P16591
Chemistry
GuidetoPHARMACOLOGY: 2022