ATP2A2 - Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 - human protein (Function)
 
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ATP2A2 »  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2   [ EC 3.6.3.8 ]  (SERCA2)
 
Protein also known as:  Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform.
Gene name:  ATP2A2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen.  
1
  • UniProtKB
Isoform  Iso 2   Is involved in the regulation of the contraction/relaxation cycle.  
2
  • UniProtKB
According to TCDB this is a transporter from family:
the p-type atpase (p-atpase) superfamily  3.A.3.2.7  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Isoforms  Iso 1 , Iso 2 and Iso 3   Calcium ion bindingdefinition[GO:0005509]  
1
  • BHF-UCL
Isoforms  Iso 1 , Iso 2 and Iso 3   Calcium-transporting ATPase activitydefinition[GO:0005388]  
1
  • BHF-UCL
Calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potentialdefinition[GO:0086039]  
3
  • BHF-UCL
  • Ortholog Curator
Enzyme bindingdefinition[GO:0019899]  
1
  • BHF-UCL
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
4
  • UniProtKB
  • IntAct
  • BHF-UCL
Isoform  Iso 1   Protein C-terminus bindingdefinition[GO:0008022]  
1
  • UniProtKB
S100 protein bindingdefinition[GO:0044548]  
1
  • UniProtKB
GO biological process 
Calcium ion import into sarcoplasmic reticulumdefinition[GO:1990036]  
2
  • BHF-UCL
  • Ortholog Curator
Calcium ion transmembrane transportdefinition[GO:0070588]  
4
  • BHF-UCL
  • Ortholog Compara
  • InterPro 2 GO
  • EC 2 GO
Isoforms  Iso 1 , Iso 2 and Iso 3   Calcium ion transport from cytosol to endoplasmic reticulumdefinition[GO:1903515]  
1
  • BHF-UCL
Cell adhesiondefinition[GO:0007155]  
1
  • PINC
Cellular calcium ion homeostasisdefinition[GO:0006874]  
2
  • BHF-UCL
  • Ortholog Compara
Isoforms  Iso 1 , Iso 2 and Iso 3   Endoplasmic reticulum calcium ion homeostasisdefinition[GO:0032469]  
2
  • BHF-UCL
Epidermis developmentdefinition[GO:0008544]  
1
  • PINC
ER-nucleus signaling pathwaydefinition[GO:0006984] silver  
1
  • Ortholog Compara
Metabolic processdefinition[GO:0008152]  
1
  • UniProtKB KW
Negative regulation of heart contractiondefinition[GO:0045822] silver  
1
  • Ortholog Compara
Isoforms  Iso 1 , Iso 2 and Iso 3   Positive regulation of endoplasmic reticulum calcium ion concentrationdefinition[GO:0032470]  
1
  • BHF-UCL
Positive regulation of heart ratedefinition[GO:0010460]  
1
  • BHF-UCL
Regulation of cardiac muscle cell action potential involved in regulation of contractiondefinition[GO:0098909]  
1
  • Ortholog Curator
Regulation of cardiac muscle cell membrane potentialdefinition[GO:0086036]  
3
  • BHF-UCL
  • GOC
  • Ortholog Curator
Isoform  Iso 2   Regulation of cardiac muscle contraction by calcium ion signalingdefinition[GO:0010882]  
1
  • BHF-UCL
Regulation of the force of heart contractiondefinition[GO:0002026] silver  
1
  • Ortholog Compara
Isoform  Iso 2   Relaxation of cardiac muscledefinition[GO:0055119]  
1
  • BHF-UCL
Sarcoplasmic reticulum calcium ion transportdefinition[GO:0070296]  
2
  • BHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.8: ATP + H(2)O + Ca(2+)(Side 1) ADP + phosphate + Ca(2+)(Side 2).  
1
  • UniProtKB
It is regulated in the following manner
Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN (By similarity).  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+488  
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+488  
Calcium signaling pathway  hsa04020+488  
Cardiac muscle contraction  hsa04260+488  
Dilated cardiomyopathy  hsa05414+488  
Hypertrophic cardiomyopathy (HCM)  hsa05410+488  
Pancreatic secretion  hsa04972+488  
According to Reactome, this protein belongs to the following pathways:
Ion transport by P-type ATPases  REACT_25149  
Pre-NOTCH Processing in Golgi  REACT_118798  
Reduction of cytosolic Ca++ levels  REACT_23765  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 488
PRO: PR:P16615