CD36 - Platelet glycoprotein 4 - human protein (Function)
 
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Protein
Gene
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CD36 »  Platelet glycoprotein 4
 
Protein also known as:  Leukocyte differentiation antigen CD36; CD antigen CD36.
Gene name:  CD36
Family name: CD36
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 259 4
GENE REF ISO

Function

 show evidences
Overview 
Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4-TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.  
4
  • UniProtKB
According to TCDB this is a transporter from family:
the long chain fatty acid translocase (lcfat) family  9.B.39.1.4  
GO molecular function 
High-density lipoprotein particle bindingdefinition[GO:0008035] silver  
1
  • Ortholog Compara
Lipid bindingdefinition[GO:0008289]  
1
  • BHF-UCL
Lipoprotein particle bindingdefinition[GO:0071813]  
1
  • UniProtKB
Lipoteichoic acid receptor activitydefinition[GO:0070892] silver  
1
  • Ortholog Compara
Low-density lipoprotein particle bindingdefinition[GO:0030169]  
1
  • BHF-UCL
Low-density lipoprotein receptor activitydefinition[GO:0005041]  
2
  • BHF-UCL
Thrombospondin receptor activitydefinition[GO:0070053]  
1
  • Ortholog Curator
Transforming growth factor beta bindingdefinition[GO:0050431]  
1
  • Ortholog Curator
GO biological process 
Apoptotic cell clearancedefinition[GO:0043277] silver  
1
  • Ortholog Compara
Cell adhesiondefinition[GO:0007155]  
1
  • UniProtKB KW
Cell surface receptor signaling pathwaydefinition[GO:0007166] silver  
1
  • Ortholog Compara
Cellular response to bacterial lipopeptidedefinition[GO:0071221] silver  
1
  • Ortholog Compara
Cellular response to hydroperoxidedefinition[GO:0071447] silver  
1
  • Ortholog Compara
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
1
  • Ortholog Compara
Cellular response to lipoteichoic aciddefinition[GO:0071223] silver  
1
  • Ortholog Compara
cGMP-mediated signalingdefinition[GO:0019934]  
1
  • BHF-UCL
Cholesterol transportdefinition[GO:0030301]  
1
  • BHF-UCL
Defense response to Gram-positive bacteriumdefinition[GO:0050830] silver  
1
  • Ortholog Compara
Lipid metabolic processdefinition[GO:0006629]  
1
  • PINC
Lipid storagedefinition[GO:0019915]  
1
  • BHF-UCL
Lipoprotein transportdefinition[GO:0042953]  
2
  • BHF-UCL
Long-chain fatty acid importdefinition[GO:0044539]  
1
  • UniProtKB
Low-density lipoprotein particle clearancedefinition[GO:0034383]  
1
  • BHF-UCL
Low-density lipoprotein particle mediated signalingdefinition[GO:0055096] silver  
1
  • Ortholog Compara
Negative regulation of growth of symbiont in hostdefinition[GO:0044130] silver  
1
  • Ortholog Compara
Negative regulation of transcription factor import into nucleusdefinition[GO:0042992] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Nitric oxide mediated signal transductiondefinition[GO:0007263]  
1
  • BHF-UCL
Phagocytosis, recognitiondefinition[GO:0006910] silver  
1
  • Ortholog Compara
Plasma lipoprotein particle clearancedefinition[GO:0034381]  
1
  • BHF-UCL
Plasma membrane long-chain fatty acid transportdefinition[GO:0015911]  
1
  • BHF-UCL
Positive regulation of blood coagulationdefinition[GO:0030194] silver  
1
  • Ortholog Compara
Positive regulation of blood microparticle formationdefinition[GO:2000334] silver  
1
  • Ortholog Compara
Positive regulation of cell-matrix adhesiondefinition[GO:0001954]  
1
  • BHF-UCL
Positive regulation of cholesterol storagedefinition[GO:0010886] silver  
1
  • Ortholog Compara
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123] silver  
1
  • Ortholog Compara
Positive regulation of interleukin-12 productiondefinition[GO:0032735] silver  
1
  • Ortholog Compara
Positive regulation of interleukin-6 productiondefinition[GO:0032755] silver  
1
  • Ortholog Compara
Positive regulation of macrophage cytokine productiondefinition[GO:0060907] silver  
1
  • Ortholog Compara
Positive regulation of macrophage derived foam cell differentiationdefinition[GO:0010744]  
1
  • BHF-UCL
Positive regulation of MAPK cascadedefinition[GO:0043410] silver  
1
  • Ortholog Compara
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731] silver  
1
  • Ortholog Compara
Positive regulation of phagocytosis, engulfmentdefinition[GO:0060100] silver  
1
  • Ortholog Compara
Positive regulation of reactive oxygen species metabolic processdefinition[GO:2000379] silver  
1
  • Ortholog Compara
Positive regulation of tumor necrosis factor productiondefinition[GO:0032760] silver  
1
  • Ortholog Compara
Regulation of removal of superoxide radicalsdefinition[GO:2000121] silver  
1
  • Ortholog Compara
Response to stilbenoiddefinition[GO:0035634] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+948  
ECM-receptor interaction  hsa04512+948  
Fat digestion and absorption  hsa04975+948  
Hematopoietic cell lineage  hsa04640+948  
Malaria  hsa05144+948  
Phagosome  hsa04145+948  
PPAR signaling pathway  hsa03320+948  
According to Reactome, this protein belongs to the following pathways:
Cross-presentation of particulate exogenous antigens (phagosomes)  REACT_111174  
MyD88:Mal cascade initiated on plasma membrane  REACT_6788  
Platelet degranulation  REACT_318  
PPARA activates gene expression  REACT_116145  
Scavenging by Class B Receptors  REACT_163679  
Toll Like Receptor TLR6:TLR2 Cascade  REACT_8006  
Transcriptional regulation of white adipocyte differentiation  REACT_27161  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Transport  definition   [KW-0813]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CD36
GenomeRNAi: 948
PRO: PR:P16671