CPE - Carboxypeptidase E - human protein (Function)
 
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CPE »  Carboxypeptidase E   [ EC 3.4.17.10 ]  (CPE)
 
Protein also known as:  Prohormone-processing carboxypeptidase.
Gene name:  CPE
Family name: Peptidase M14
Entry whose protein(s) existence is based on evidence at protein level
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1 37 2
GENE REF ISO

Function

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Overview 
Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.  
  • CuratedUniProtKB
GO molecular function 
Carboxypeptidase activitydefinition[GO:0004180]  
1
  • TASPINC
Cell adhesion molecule bindingdefinition[GO:0050839]  
1
  • IPIBHF-UCL
Metallocarboxypeptidase activitydefinition[GO:0004181] silver  
  • IEAInterPro 2 GO
Neurexin family protein bindingdefinition[GO:0042043]  
1
  • IPIBHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Cardiac left ventricle morphogenesisdefinition[GO:0003214]  
1
  • IMPBHF-UCL
Cellular protein modification processdefinition[GO:0006464]  
1
  • NASUniProtKB
Insulin processingdefinition[GO:0030070] silver  
  • IEAOrtholog Compara
Metabolic processdefinition[GO:0008152]  
1
  • TASPINC
Neuropeptide signaling pathwaydefinition[GO:0007218]  
1
  • NASUniProtKB
Protein localization to membranedefinition[GO:0072657]  
1
  • IDABHF-UCL
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.17.10: Release of C-terminal arginine or lysine residues from polypeptides.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Type I diabetes mellitus  hsa04940+1363  
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
 

Keywords

Molecular function 
Carboxypeptidase  definition   [KW-0121]
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Carboxypeptidase_E
GenomeRNAi: 1363
PRO: PR:P16870