IL7R - Interleukin-7 receptor subunit alpha - human protein (Function)
 
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IL7R »  Interleukin-7 receptor subunit alpha  (IL-7RA)
 
Protein also known as:  CDw127; CD antigen CD127.
Gene name:  IL7R
Entry whose protein(s) existence is based on evidence at protein level
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1 148 4
GENE REF ISO

Function

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Overview 
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).  
  • CuratedUniProtKB
GO molecular function 
Antigen bindingdefinition[GO:0003823]  
1
  • TASPINC
Interleukin-7 receptor activitydefinition[GO:0004917]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
B cell proliferationdefinition[GO:0042100] silver  
  • IEAOrtholog Compara
Cell growthdefinition[GO:0016049] silver  
  • IEAOrtholog Compara
Cell morphogenesisdefinition[GO:0000902] silver  
  • IEAOrtholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Homeostasis of number of cellsdefinition[GO:0048872] silver  
  • IEAOrtholog Compara
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Immunoglobulin productiondefinition[GO:0002377] silver  
  • IEAOrtholog Compara
Interleukin-7-mediated signaling pathwaydefinition[GO:0038111]  
1
  • TASGOC
Lymph node developmentdefinition[GO:0048535] silver  
  • IEAOrtholog Compara
Negative regulation of T cell mediated cytotoxicitydefinition[GO:0001915] silver  
  • IEAOrtholog Compara
Positive regulation of gene expressiondefinition[GO:0010628] silver  
  • IEAOrtholog Compara
Positive regulation of T cell differentiation in thymusdefinition[GO:0033089] silver  
  • IEAOrtholog Compara
Regulation of cell sizedefinition[GO:0008361] silver  
  • IEAOrtholog Compara
Regulation of DNA recombinationdefinition[GO:0000018]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
T cell differentiationdefinition[GO:0030217] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+3575  
Hematopoietic cell lineage  hsa04640+3575  
Jak-STAT signaling pathway  hsa04630+3575  
Primary immunodeficiency  hsa05340+3575  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links