PLCG2 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 - human protein (Function)
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PLCG2 »  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2   [ EC ]
Protein also known as:  Phosphoinositide phospholipase C-gamma-2.
Gene name:  PLCG2
Entry whose protein(s) existence is based on evidence at protein level
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The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.  
  • CuratedUniProtKB
GO molecular function 
Phosphatidylinositol phospholipase C activitydefinition[GO:0004435]  
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
  • IPIIntAct
Signal transducer activitydefinition[GO:0004871]  
  • IEAUniProtKB KW
GO biological process 
Activation of store-operated calcium channel activitydefinition[GO:0032237] silver  
  • IEAOrtholog Compara
B cell differentiationdefinition[GO:0030183]  
  • ISSOrtholog Curator
B cell receptor signaling pathwaydefinition[GO:0050853]  
  • ISSOrtholog Curator
Calcium-mediated signalingdefinition[GO:0019722]  
  • NASUniProtKB
Follicular B cell differentiationdefinition[GO:0002316] silver  
  • IEAOrtholog Compara
Inositol trisphosphate biosynthetic processdefinition[GO:0032959] silver  
  • IEAOrtholog Compara
Negative regulation of programmed cell deathdefinition[GO:0043069] silver  
  • IEAOrtholog Compara
Phosphatidylinositol biosynthetic processdefinition[GO:0006661]  
  • IDAUniProtKB
Phospholipid catabolic processdefinition[GO:0009395] silver  
  • IEAInterPro 2 GO
Regulation of gene expressiondefinition[GO:0010468] silver  
  • IEAOrtholog Compara
Release of sequestered calcium ion into cytosoldefinition[GO:0051209]  
  • IDAUniProtKB
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
T cell receptor signaling pathwaydefinition[GO:0050852]  
  • ISSOrtholog Curator
Wnt signaling pathwaydefinition[GO:0016055]  
  • TASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.  
  • CuratedUniProtKB
It requires the following cofactor
  • CuratedUniProtKB
More information is available from:
According to KEGG, this protein belongs to the following pathways:
B cell receptor signaling pathway  hsa04662+5336  
Calcium signaling pathway  hsa04020+5336  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+5336  
ErbB signaling pathway  hsa04012+5336  
Fc epsilon RI signaling pathway  hsa04664+5336  
Fc gamma R-mediated phagocytosis  hsa04666+5336  
Glioma  hsa05214+5336  
Inositol phosphate metabolism  hsa00562+5336  
Leukocyte transendothelial migration  hsa04670+5336  
Metabolic pathways  hsa01100+5336  
Natural killer cell mediated cytotoxicity  hsa04650+5336  
Neurotrophin signaling pathway  hsa04722+5336  
Non-small cell lung cancer  hsa05223+5336  
Osteoclast differentiation  hsa04380+5336  
Pathways in cancer  hsa05200+5336  
Phosphatidylinositol signaling system  hsa04070+5336  
VEGF signaling pathway  hsa04370+5336  
Vibrio cholerae infection  hsa05110+5336  
According to Reactome, this protein belongs to the following pathways:
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  REACT_118700  
DAP12 signaling  REACT_147814  
FCERI mediated Ca+2 mobilization  REACT_163834  
FCERI mediated MAPK activation  REACT_163701  
GPVI-mediated activation cascade  REACT_1695  
Role of phospholipids in phagocytosis  REACT_160158  
Synthesis of IP3 and IP4 in the cytosol  REACT_150312  
Toll Like Receptor 4 (TLR4) Cascade  REACT_6894  
More information is available from:


Biological process 
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Hydrolase  definition   [KW-0378]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: PLCG2
GenomeRNAi: 5336
PRO: PR:P16885