PLCG2 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
PLCG2 »  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2   [ EC 3.1.4.11 ]
 
Protein also known as:  Phosphoinositide phospholipase C-gamma-2.
Gene name:  PLCG2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 54 1
GENE REF ISO

Function

 show evidences
Overview 
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.  
  • CuratedUniProtKB
GO molecular function 
Phosphatidylinositol phospholipase C activitydefinition[GO:0004435]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Signal transducer activitydefinition[GO:0004871]  
  • IEAUniProtKB KW
GO biological process 
Activation of store-operated calcium channel activitydefinition[GO:0032237] silver  
  • IEAOrtholog Compara
B cell differentiationdefinition[GO:0030183]  
  • ISSOrtholog Curator
B cell receptor signaling pathwaydefinition[GO:0050853]  
  • ISSOrtholog Curator
Calcium-mediated signalingdefinition[GO:0019722]  
1
  • NASUniProtKB
Follicular B cell differentiationdefinition[GO:0002316] silver  
  • IEAOrtholog Compara
Inositol trisphosphate biosynthetic processdefinition[GO:0032959] silver  
  • IEAOrtholog Compara
Negative regulation of programmed cell deathdefinition[GO:0043069] silver  
  • IEAOrtholog Compara
Phosphatidylinositol biosynthetic processdefinition[GO:0006661]  
2
  • IDAUniProtKB
Phospholipid catabolic processdefinition[GO:0009395] silver  
  • IEAInterPro 2 GO
Regulation of gene expressiondefinition[GO:0010468] silver  
  • IEAOrtholog Compara
Release of sequestered calcium ion into cytosoldefinition[GO:0051209]  
1
  • IDAUniProtKB
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
T cell receptor signaling pathwaydefinition[GO:0050852]  
  • ISSOrtholog Curator
Wnt signaling pathwaydefinition[GO:0016055]  
1
  • TASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.4.11: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.  
  • CuratedUniProtKB
It requires the following cofactor
Calcium.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
B cell receptor signaling pathway  hsa04662+5336  
Calcium signaling pathway  hsa04020+5336  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+5336  
ErbB signaling pathway  hsa04012+5336  
Fc epsilon RI signaling pathway  hsa04664+5336  
Fc gamma R-mediated phagocytosis  hsa04666+5336  
Glioma  hsa05214+5336  
Inositol phosphate metabolism  hsa00562+5336  
Leukocyte transendothelial migration  hsa04670+5336  
Metabolic pathways  hsa01100+5336  
Natural killer cell mediated cytotoxicity  hsa04650+5336  
Neurotrophin signaling pathway  hsa04722+5336  
Non-small cell lung cancer  hsa05223+5336  
Osteoclast differentiation  hsa04380+5336  
Pathways in cancer  hsa05200+5336  
Phosphatidylinositol signaling system  hsa04070+5336  
VEGF signaling pathway  hsa04370+5336  
Vibrio cholerae infection  hsa05110+5336  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Immune System  REACT_6900  
Metabolism  REACT_111217  
PLC-mediated hydrolysis of PIP2  REACT_2080  
 
More information is available from:
 

Keywords

Biological process 
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Hydrolase  definition   [KW-0378]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PLCG2
GenomeRNAi: 5336
PRO: PR:P16885