IFNAR1 - Interferon alpha/beta receptor 1 - human protein (Function)
 
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IFNAR1 »  Interferon alpha/beta receptor 1  (IFN-R-1)
 
Protein also known as:  Cytokine receptor class-II member 1.
Gene name:  IFNAR1
Entry whose protein(s) existence is based on evidence at protein level
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1 101 3
GENE REF ISO

Function

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Overview 
Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
Type I interferon receptor activitydefinition[GO:0004905]  
1
  • TASPINC
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Defense response to virusdefinition[GO:0051607] silver  
  • IEAOrtholog Compara
JAK-STAT cascadedefinition[GO:0007259]  
1
  • TASPINC
Positive regulation of interferon-gamma productiondefinition[GO:0032729] silver  
  • IEAOrtholog Compara
Response to virusdefinition[GO:0009615]  
1
  • TASPINC
T cell activationdefinition[GO:0042110] silver  
  • IEAOrtholog Compara
Type I interferon biosynthetic processdefinition[GO:0045351] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+3454  
Hepatitis C  hsa05160+3454  
Herpes simplex infection  hsa05168+3454  
Influenza A  hsa05164+3454  
Jak-STAT signaling pathway  hsa04630+3454  
Measles  hsa05162+3454  
Natural killer cell mediated cytotoxicity  hsa04650+3454  
Osteoclast differentiation  hsa04380+3454  
Toll-like receptor signaling pathway  hsa04620+3454  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IFNAR1
GenomeRNAi: 3454
PRO: PR:P17181