BPI - Bactericidal permeability-increasing protein - human protein (Function)
 
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BPI »  Bactericidal permeability-increasing protein  (BPI)
 
Protein also known as:  CAP 57.
Gene name:  BPI
Family name: BPI/LBP/Plunc » BPI/LBP
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.  
3
  • UniProtKB
According to TCDB this is a transporter from family:
the bactericidal permeability increasing protein (bpip) family  1.C.40.1.1  
GO molecular function 
Lipopolysaccharide bindingdefinition[GO:0001530]  
1
  • BHF-UCL
GO biological process 
Defense response to Gram-negative bacteriumdefinition[GO:0050829] silver  
1
  • InterPro 2 GO
Immune responsedefinition[GO:0006955] silver  
1
  • Ortholog Compara
Negative regulation of interleukin-6 productiondefinition[GO:0032715]  
1
  • BHF-UCL
Negative regulation of interleukin-8 productiondefinition[GO:0032717]  
1
  • BHF-UCL
Negative regulation of macrophage activationdefinition[GO:0043031]  
1
  • BHF-UCL
Negative regulation of tumor necrosis factor productiondefinition[GO:0032720]  
1
  • BHF-UCL
 

Keywords

Molecular function 
Antibiotic  definition   [KW-0044]
Antimicrobial  definition   [KW-0929]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 671
PRO: PR:P17213