SMPD1 - Sphingomyelin phosphodiesterase - human protein (Function)
 
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SMPD1 »  Sphingomyelin phosphodiesterase   [ EC 3.1.4.12 ]
 
Protein also known as:  Acid sphingomyelinase (aSMase).
Gene name:  SMPD1
Family name: Acid sphingomyelinase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.  
  • CuratedUniProtKB
Isoforms  Iso 2 and Iso 3   Have lost catalytic activity.  
  • CuratedUniProtKB
GO molecular function 
Hydrolase activity, acting on glycosyl bondsdefinition[GO:0016798]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Sphingomyelin phosphodiesterase activitydefinition[GO:0004767]  
  • IEAEC 2 GO
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Ceramide biosynthetic processdefinition[GO:0046513]  
1
  • IMPBHF-UCL
Negative regulation of MAP kinase activitydefinition[GO:0043407]  
1
  • IMPBHF-UCL
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Positive regulation of protein dephosphorylationdefinition[GO:0035307]  
1
  • IMPBHF-UCL
Response to cocainedefinition[GO:0042220] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Sphingomyelin catabolic processdefinition[GO:0006685] silver  
  • IEAInterPro 2 GO
Sphingomyelin metabolic processdefinition[GO:0006684]  
1
  • TASPINC
Termination of signal transductiondefinition[GO:0023021]  
1
  • IMPBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.4.12: Sphingomyelin + H(2)O N-acylsphingosine + phosphocholine.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Lysosome  hsa04142+6609  
Metabolic pathways  hsa01100+6609  
Sphingolipid metabolism  hsa00600+6609  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
Note 
There are two types of sphingomyelinases: ASM (acid), and NSM (neutral).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Glycosidase  definition   [KW-0326]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links