AKR1C4 - Aldo-keto reductase family 1 member C4 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
AKR1C4 »  Aldo-keto reductase family 1 member C4   [ EC 1.1.1.- ]
 
Protein also known as:  3-alpha-hydroxysteroid dehydrogenase type I [EC 1.1.1.357].
Gene name:  AKR1C4
Family name: Aldo/keto reductase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 33 1
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.  
  • CuratedUniProtKB
GO molecular function 
Aldo-keto reductase (NADP) activitydefinition[GO:0004033]  
1
  • TASPINC
Androsterone dehydrogenase activitydefinition[GO:0047023]  
1
  • IDAUniProtKB
Bile acid transmembrane transporter activitydefinition[GO:0015125]  
1
  • TASPINC
Chlordecone reductase activitydefinition[GO:0047743]  
  • IEAEC 2 GO
Electron carrier activitydefinition[GO:0009055]  
1
  • TASUniProtKB
Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptordefinition[GO:0016655]  
1
  • IDAUniProtKB
Retinal dehydrogenase activitydefinition[GO:0001758]  
1
  • IDAUniProtKB
GO biological process 
Androgen metabolic processdefinition[GO:0008209]  
1
  • TASPINC
Bile acid and bile salt transportdefinition[GO:0015721]  
1
  • TASPINC
Cellular response to jasmonic acid stimulusdefinition[GO:0071395]  
1
  • IDAUniProtKB
Daunorubicin metabolic processdefinition[GO:0044597]  
1
  • IMPUniProtKB
Doxorubicin metabolic processdefinition[GO:0044598]  
1
  • IMPUniProtKB
Ion transmembrane transportdefinition[GO:0034220]  
1
  • TASGOC
Lipid transportdefinition[GO:0006869]  
1
  • TASGOC
Steroid metabolic processdefinition[GO:0008202]  
1
  • TASPINC
Transmembrane transportdefinition[GO:0055085]  
1
  • TASGOC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 1.1.1.225: Chlordecone alcohol + NADP(+) chlordecone + NADPH.  
  • CuratedUniProtKB
EC 1.1.1.357: A 3-alpha-hydroxysteroid + NAD(P)(+) a 3-oxosteroid + NAD(P)H.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+1109  
Metabolism of xenobiotics by cytochrome P450  hsa00980+1109  
Primary bile acid biosynthesis  hsa00120+1109  
Steroid hormone biosynthesis  hsa00140+1109  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P17516
Other
GeneWiki: 3-alpha-HSD
GenomeRNAi: 1109
PRO: PR:P17516