TAL1 - T-cell acute lymphocytic leukemia protein 1 - human protein (Function)
 
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Protein
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TAL1 »  T-cell acute lymphocytic leukemia protein 1  (TAL-1)
 
Protein also known as:  Class A basic helix-loop-helix protein 17 (bHLHa17).
Gene name:  TAL1
Entry whose protein(s) existence is based on evidence at protein level
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1 74 3
GENE REF ISO

Function

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Overview 
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
1
  • IDAMGI
E-box bindingdefinition[GO:0070888]  
1
  • IDABHF-UCL
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIBHF-UCL
Histone deacetylase bindingdefinition[GO:0042826]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980] silver  
  • IEAOrtholog Compara
RNA polymerase II transcription factor bindingdefinition[GO:0001085]  
1
  • IPIBHF-UCL
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDABHF-UCL
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
  • ISSOrtholog Curator
GO biological process 
Angiogenesisdefinition[GO:0001525] silver  
  • IEAOrtholog Compara
Astrocyte fate commitmentdefinition[GO:0060018] silver  
  • IEAOrtholog Compara
Basophil differentiationdefinition[GO:0030221]  
1
  • IEPBHF-UCL
Cell fate commitmentdefinition[GO:0045165]  
  • ISSOrtholog Curator
Definitive hemopoiesisdefinition[GO:0060216] silver  
  • IEAOrtholog Compara
Embryonic hemopoiesisdefinition[GO:0035162]  
  • ISSOrtholog Curator
Erythrocyte differentiationdefinition[GO:0030218]  
2
  • IEPBHF-UCL
Erythrocyte maturationdefinition[GO:0043249] silver  
  • IEAOrtholog Compara
Hemangioblast cell differentiationdefinition[GO:0060217] silver  
  • IEAOrtholog Compara
Hematopoietic stem cell differentiationdefinition[GO:0060218] silver  
  • IEAOrtholog Compara
Hemopoiesisdefinition[GO:0030097]  
  • ISSOrtholog Curator
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAOrtholog Compara
Megakaryocyte developmentdefinition[GO:0035855] silver  
  • IEAOrtholog Compara
Megakaryocyte differentiationdefinition[GO:0030219]  
1
  • IEPBHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Platelet formationdefinition[GO:0030220] silver  
  • IEAOrtholog Compara
Positive regulation of cell divisiondefinition[GO:0051781]  
1
  • IMPBHF-UCL
Positive regulation of chromatin assembly or disassemblydefinition[GO:0045799]  
1
  • IMPBHF-UCL
Positive regulation of erythrocyte differentiationdefinition[GO:0045648]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Positive regulation of mitotic cell cycledefinition[GO:0045931]  
1
  • IMPBHF-UCL
Positive regulation of protein complex assemblydefinition[GO:0031334]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Regulation of cell proliferationdefinition[GO:0042127] silver  
  • IEAOrtholog Compara
Regulation of mast cell differentiationdefinition[GO:0060375] silver  
  • IEAOrtholog Compara
Regulation of stem cell maintenancedefinition[GO:2000036] silver  
  • IEAOrtholog Compara
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
  • ISSOrtholog Curator
Spinal cord association neuron differentiationdefinition[GO:0021527] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TAL1
GenomeRNAi: 6886
PRO: PR:P17542