ATF7 - Cyclic AMP-dependent transcription factor ATF-7 - human protein (Function)
 
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ATF7 »  Cyclic AMP-dependent transcription factor ATF-7
 
Gene name:  ATF7
Family name: bZIP
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.  
8
  • CuratedUniProtKB
GO molecular function 
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Mitogen-activated protein kinase bindingdefinition[GO:0051019]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
Transcription factor bindingdefinition[GO:0008134]  
1
  • IDAUniProtKB
GO biological process 
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IDAUniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATF7
GenomeRNAi: 11016
PRO: PR:P17544