ATF7 - Cyclic AMP-dependent transcription factor ATF-7 - human protein (Function)
 
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ATF7 »  Cyclic AMP-dependent transcription factor ATF-7  (cAMP-dependent transcription factor ATF-7)
 
Protein also known as:  Activating transcription factor 7.
Gene name:  ATF7
Family name: bZIP
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.  
1
  • UniProtKB
GO molecular function 
Enzyme bindingdefinition[GO:0019899]  
1
  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Mitogen-activated protein kinase bindingdefinition[GO:0051019]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
Isoform  Iso 4   RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • NTNU_SB
Isoform  Iso 4   RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001078]  
1
  • NTNU_SB
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
1
  • InterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
1
  • InterPro 2 GO
Transcription factor bindingdefinition[GO:0008134]  
1
  • UniProtKB
GO biological process 
Isoform  Iso 4   Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • NTNU_SB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATF7
GenomeRNAi: 11016
PRO: PR:P17544