CAPN2 - Calpain-2 catalytic subunit - human protein (Function)
 
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CAPN2 »  Calpain-2 catalytic subunit   [ EC 3.4.22.53 ]
 
Protein also known as:  Calcium-activated neutral proteinase 2 (CANP 2).
Gene name:  CAPN2
Family name: Peptidase C2
Entry whose protein(s) existence is based on evidence at protein level
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1 95 2
GENE REF ISO

Function

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Overview 
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed17650508).  
1
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAOrtholog Compara
Calcium-dependent cysteine-type endopeptidase activitydefinition[GO:0004198]  
  • ISSOrtholog Curator
  • IBARefGenome
Cysteine-type peptidase activitydefinition[GO:0008234]  
1
  • TASPINC
Cytoskeletal protein bindingdefinition[GO:0008092]  
1
  • NASBHF-UCL
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
GO biological process 
Blastocyst developmentdefinition[GO:0001824] silver  
  • IEAOrtholog Compara
Cellular response to amino acid stimulusdefinition[GO:0071230]  
  • ISSOrtholog Curator
Myoblast fusiondefinition[GO:0007520] silver  
  • IEAOrtholog Compara
Protein autoprocessingdefinition[GO:0016540] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
  • IBARefGenome
  • ISSOrtholog Curator
Proteolysis involved in cellular protein catabolic processdefinition[GO:0051603]  
1
  • ICBHF-UCL
Regulation of cytoskeleton organizationdefinition[GO:0051493]  
1
  • TASBHF-UCL
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.53: Broad endopeptidase specificity.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 7 calcium ions (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+824  
Apoptosis  hsa04210+824  
Focal adhesion  hsa04510+824  
Protein processing in endoplasmic reticulum  hsa04141+824  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CAPN2
GenomeRNAi: 824
PRO: PR:P17655