KCNA6 - Potassium voltage-gated channel subfamily A member 6 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
KCNA6 »  Potassium voltage-gated channel subfamily A member 6
 
Protein also known as:  Voltage-gated potassium channel subunit Kv1.6.
Gene name:  KCNA6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 24 1
GENE REF ISO

Function

 show evidences
Overview 
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed2347305, PubMed14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed2347305, PubMed14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed2347305).  
4
  • UniProtKB
GO molecular function 
Delayed rectifier potassium channel activitydefinition[GO:0005251]  
2
  • UniProtKB
  • RefGenome
Voltage-gated potassium channel activitydefinition[GO:0005249]  
1
  • PINC
GO biological process 
Potassium ion transmembrane transportdefinition[GO:0071805]  
2
  • UniProtKB
  • RefGenome
Potassium ion transportdefinition[GO:0006813]  
1
  • PINC
Protein homooligomerizationdefinition[GO:0051260] silver  
1
  • InterPro 2 GO
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • UniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
Voltage gated Potassium channels  REACT_75770  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNA6
GenomeRNAi: 3742
PRO: PR:P17658
Chemistry
GuidetoPHARMACOLOGY: 543