DES - Desmin - human protein (Function)
 
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Protein
Gene
References

 
DES »  Desmin
 
Gene name:  DES
Family name: Intermediate filament
Entry whose protein(s) existence is based on evidence at protein level
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1 103 1
GENE REF ISO

Function

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Overview 
Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.  
  • CuratedUniProtKB
GO molecular function 
Cytoskeletal protein bindingdefinition[GO:0008092]  
1
  • IPIBHF-UCL
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Structural constituent of cytoskeletondefinition[GO:0005200]  
1
  • TASPINC
GO biological process 
Cytoskeleton organizationdefinition[GO:0007010]  
1
  • TASPINC
Muscle contractiondefinition[GO:0006936]  
1
  • TASPINC
Regulation of heart contractiondefinition[GO:0008016]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+1674  
Dilated cardiomyopathy  hsa05414+1674  
Hypertrophic cardiomyopathy (HCM)  hsa05410+1674  
According to Reactome, this protein belongs to the following pathway:
Muscle contraction  REACT_17044  
 

Keywords

Molecular function 
Muscle protein  definition   [KW-0514]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Desmin
GenomeRNAi: 1674
PRO: PR:P17661