CEBPB - CCAAT/enhancer-binding protein beta - human protein (Function)
 
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CEBPB »  CCAAT/enhancer-binding protein beta  (C/EBP beta)
 
Protein also known as:  Liver-enriched inhibitory protein (LIP).
Gene name:  CEBPB
Family name: bZIP » C/EBP
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed9374525, PubMed12048245, PubMed18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis (By similarity).  
7
  • UniProtKB
Isoform  Iso 2   Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing.  
2
  • UniProtKB
Isoform  Iso 3   Acts as a dominant negative through heterodimerization with isoform 2 (PubMed11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity).  
4
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
1
  • Ortholog Compara
DNA bindingdefinition[GO:0003677]  
1
  • PINC
Glucocorticoid receptor bindingdefinition[GO:0035259] silver  
1
  • Ortholog Compara
Histone acetyltransferase bindingdefinition[GO:0035035] silver  
1
  • Ortholog Compara
Histone deacetylase bindingdefinition[GO:0042826] silver  
1
  • Ortholog Compara
Kinase bindingdefinition[GO:0019900] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
7
  • IntAct
  • UniProtKB
  • BHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • ParkinsonsUK-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • Ortholog Curator
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
1
  • Ortholog Compara
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • MGI
Transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingdefinition[GO:0003705]  
1
  • Ortholog Curator
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
1
  • PINC
Transcription factor bindingdefinition[GO:0008134] silver  
1
  • Ortholog Compara
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingdefinition[GO:0001077] silver  
1
  • Ortholog Compara
Ubiquitin-like protein ligase bindingdefinition[GO:0044389] silver  
1
  • Ortholog Compara
GO biological process 
Acute-phase responsedefinition[GO:0006953]  
1
  • PINC
Brown fat cell differentiationdefinition[GO:0050873] silver  
1
  • Ortholog Compara
Cellular response to amino acid stimulusdefinition[GO:0071230] silver  
1
  • Ortholog Compara
Defense response to bacteriumdefinition[GO:0042742]  
1
  • Ortholog Curator
Embryonic placenta developmentdefinition[GO:0001892] silver  
1
  • Ortholog Compara
Granuloma formationdefinition[GO:0002432]  
2
  • Ortholog Curator
  • Ortholog Compara
Hepatocyte proliferationdefinition[GO:0072574]  
1
  • Ortholog Curator
Immune responsedefinition[GO:0006955]  
1
  • PINC
Inflammatory responsedefinition[GO:0006954]  
1
  • PINC
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:0070059] silver  
1
  • Ortholog Compara
Liver regenerationdefinition[GO:0097421]  
1
  • Ortholog Curator
Mammary gland epithelial cell differentiationdefinition[GO:0060644] silver  
1
  • Ortholog Compara
Mammary gland epithelial cell proliferationdefinition[GO:0033598] silver  
1
  • Ortholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Negative regulation of T cell proliferationdefinition[GO:0042130]  
1
  • Ortholog Curator
Negative regulation of transcription, DNA-templateddefinition[GO:0045892] silver  
1
  • Ortholog Compara
Neuron differentiationdefinition[GO:0030182] silver  
1
  • Ortholog Compara
Ovarian follicle developmentdefinition[GO:0001541]  
1
  • Ortholog Curator
Positive regulation of fat cell differentiationdefinition[GO:0045600]  
1
  • Ortholog Curator
Positive regulation of interleukin-4 productiondefinition[GO:0032753]  
1
  • Ortholog Curator
Positive regulation of osteoblast differentiationdefinition[GO:0045669] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • MGI
Positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stressdefinition[GO:1990440]  
1
  • ParkinsonsUK-UCL
Regulation of interleukin-6 biosynthetic processdefinition[GO:0045408] silver  
1
  • Ortholog Compara
Regulation of osteoclast differentiationdefinition[GO:0045670]  
1
  • Ortholog Curator
Regulation of transcription involved in cell fate commitmentdefinition[GO:0060850]  
1
  • Ortholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
1
  • UniProtKB
Response to lipopolysaccharidedefinition[GO:0032496] silver  
1
  • Ortholog Compara
T-helper 1 cell activationdefinition[GO:0035711]  
2
  • Ortholog Curator
  • Ortholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Tuberculosis  hsa05152+1051  
According to Reactome, this protein belongs to the following pathways:
Senescence-Associated Secretory Phenotype (SASP)  R-HSA-2559582  
Transcriptional regulation of white adipocyte differentiation  R-HSA-381340  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CEBPB
GenomeRNAi: 1051
PRO: PR:P17676