CEBPB - CCAAT/enhancer-binding protein beta - human protein (Function)
 
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CEBPB »  CCAAT/enhancer-binding protein beta  (C/EBP beta)
 
Protein also known as:  Liver-enriched inhibitory protein (LIP).
Gene name:  CEBPB
Family name: bZIP » C/EBP
Entry whose protein(s) existence is based on evidence at protein level
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1 231 3
GENE REF ISO

Function

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Overview 
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Plays an important role in adipose tissue differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG) as well as other adipogenesis key player genes.  
2
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • TASPINC
Glucocorticoid receptor bindingdefinition[GO:0035259] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
5
  • IPIUniProtKB
  • IPIIntAct
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
  • IEAOrtholog Compara
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705]  
  • ISSOrtholog Curator
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • NASPINC
Transcription factor bindingdefinition[GO:0008134] silver  
  • IEAOrtholog Compara
GO biological process 
Acute-phase responsedefinition[GO:0006953]  
1
  • TASPINC
Brown fat cell differentiationdefinition[GO:0050873] silver  
  • IEAOrtholog Compara
Cellular response to amino acid stimulusdefinition[GO:0071230] silver  
  • IEAOrtholog Compara
Embryonic placenta developmentdefinition[GO:0001892] silver  
  • IEAOrtholog Compara
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Inflammatory responsedefinition[GO:0006954]  
1
  • TASPINC
Mammary gland epithelial cell differentiationdefinition[GO:0060644] silver  
  • IEAOrtholog Compara
Mammary gland epithelial cell proliferationdefinition[GO:0033598] silver  
  • IEAOrtholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892] silver  
  • IEAOrtholog Compara
Neuron differentiationdefinition[GO:0030182] silver  
  • IEAOrtholog Compara
Positive regulation of fat cell differentiationdefinition[GO:0045600]  
  • ISSOrtholog Curator
Positive regulation of osteoblast differentiationdefinition[GO:0045669] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Regulation of interleukin-6 biosynthetic processdefinition[GO:0045408] silver  
  • IEAOrtholog Compara
Regulation of transcription involved in cell fate commitmentdefinition[GO:0060850]  
  • ISSOrtholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IDAUniProtKB
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
1
  • IDAUniProtKB
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Tuberculosis  hsa05152+1051  
According to Reactome, this protein belongs to the following pathways:
Senescence-Associated Secretory Phenotype (SASP)  REACT_169168  
Transcriptional regulation of white adipocyte differentiation  REACT_27161  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CEBPB
GenomeRNAi: 1051
PRO: PR:P17676