GAP43 - Neuromodulin - human protein (Function)
 
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Protein
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GAP43 »  Neuromodulin
 
Protein also known as:  Axonal membrane protein GAP-43.
Gene name:  GAP43
Family name: Neuromodulin
Entry whose protein(s) existence is based on evidence at protein level
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1 42 2
GENE REF ISO

Function

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Overview 
This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the brain acid-soluble protein channel (basp1 channel) family  1.A.71.2.1  
GO molecular function 
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Axon choice point recognitiondefinition[GO:0016198] silver  
  • IEAOrtholog Compara
Cell fate commitmentdefinition[GO:0045165] silver  
  • IEAOrtholog Compara
Glial cell differentiationdefinition[GO:0010001] silver  
  • IEAOrtholog Compara
Protein kinase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007205]  
1
  • TASPINC
Regulation of filopodium assemblydefinition[GO:0051489]  
1
  • IDAUniProtKB
Regulation of growthdefinition[GO:0040008]  
  • IEAUniProtKB KW
Response to woundingdefinition[GO:0009611]  
1
  • TASPINC
Tissue regenerationdefinition[GO:0042246] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Growth regulation  definition   [KW-0341]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Gap-43_protein
GenomeRNAi: 2596
PRO: PR:P17677