AMD1 - S-adenosylmethionine decarboxylase proenzyme - human protein (Function)
 
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Protein
Gene
References

 
AMD1 »  S-adenosylmethionine decarboxylase proenzyme   [ EC 4.1.1.50 ]  (SAMDC)
 
Cleaved into:  S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain.
Gene name:  AMD1
Family name: Eukaryotic AdoMetDC
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 34 2
GENE REF ISO

Function

 show evidences
GO molecular function 
Adenosylmethionine decarboxylase activitydefinition[GO:0004014]  
2
  • TASUniProtKB
GO biological process 
S-adenosylmethioninamine biosynthetic processdefinition[GO:0006557]  
  • IEAUniPathway
Spermidine biosynthetic processdefinition[GO:0008295]  
  • IEAUniProtKB KW
Spermine biosynthetic processdefinition[GO:0006597] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.1.1.50: S-adenosyl-L-methionine S-adenosyl 3-(methylthio)propylamine + CO(2).  
1
  • CuratedUniProtKB
It requires the following cofactor
Pyruvoyl group.  
  • CuratedUniProtKB
It is regulated in the following manner
Both proenzyme processing and catalytic activity are stimulated by putrescine. Catalytic activity is inhibited by iodoacetic acid.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Arginine and proline metabolism  hsa00330+262  
Cysteine and methionine metabolism  hsa00270+262  
Metabolic pathways  hsa01100+262  
According to Reactome, this protein belongs to the following pathway:
Metabolism of polyamines  REACT_14820  
 

Keywords

Biological process 
Polyamine biosynthesis  definition   [KW-0620]
Spermidine biosynthesis  definition   [KW-0745]
Molecular function 
Decarboxylase  definition   [KW-0210]
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P17707
Other
GenomeRNAi: 262
PRO: PR:P17707