CHRNB2 - Neuronal acetylcholine receptor subunit beta-2 - human protein (Function)
 
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CHRNB2 »  Neuronal acetylcholine receptor subunit beta-2
 
Gene name:  CHRNB2
Entry whose protein(s) existence is based on evidence at protein level
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1 74 1
GENE REF ISO

Function

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Overview 
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family  1.A.9.1.6  
GO molecular function 
Acetylcholine bindingdefinition[GO:0042166]  
2
  • IMPUniProtKB
Acetylcholine receptor activitydefinition[GO:0015464]  
1
  • IDAUniProtKB
Acetylcholine-activated cation-selective channel activitydefinition[GO:0004889]  
2
  • TASDFLAT
  • IDAUniProtKB
Drug bindingdefinition[GO:0008144] silver  
  • IEAOrtholog Compara
Ligand-gated ion channel activitydefinition[GO:0015276]  
1
  • TASDFLAT
GO biological process 
Action potentialdefinition[GO:0001508] silver  
  • IEAOrtholog Compara
Associative learningdefinition[GO:0008306]  
  • ISSOrtholog Curator
B cell activationdefinition[GO:0042113]  
  • ISSOrtholog Curator
Behavioral response to nicotinedefinition[GO:0035095]  
1
  • IMPUniProtKB
Calcium ion transportdefinition[GO:0006816]  
  • ISSOrtholog Curator
Central nervous system projection neuron axonogenesisdefinition[GO:0021952]  
  • ISSOrtholog Curator
Cognitiondefinition[GO:0050890]  
1
  • IMPUniProtKB
Conditioned taste aversiondefinition[GO:0001661] silver  
  • IEAOrtholog Compara
Ion transmembrane transportdefinition[GO:0034220]  
1
  • TASGOC
  • IEAInterPro 2 GO
Ion transportdefinition[GO:0006811]  
1
  • NASUniProtKB
Lateral geniculate nucleus developmentdefinition[GO:0021771]  
  • ISSOrtholog Curator
Learningdefinition[GO:0007612]  
1
  • IMPUniProtKB
Locomotory behaviordefinition[GO:0007626]  
  • ISSOrtholog Curator
Membrane depolarizationdefinition[GO:0051899]  
  • ISSOrtholog Curator
Memorydefinition[GO:0007613]  
1
  • IMPUniProtKB
Negative regulation of action potentialdefinition[GO:0045759]  
  • ISSOrtholog Curator
Neurological system processdefinition[GO:0050877]  
1
  • IMPUniProtKB
Optic nerve morphogenesisdefinition[GO:0021631]  
  • ISSOrtholog Curator
Positive regulation of B cell proliferationdefinition[GO:0030890]  
  • ISSOrtholog Curator
Positive regulation of dopamine secretiondefinition[GO:0033603]  
  • ISSOrtholog Curator
Positive regulation of synaptic transmission, dopaminergicdefinition[GO:0032226] silver  
  • IEAOrtholog Compara
Protein heterooligomerizationdefinition[GO:0051291] silver  
  • IEAOrtholog Compara
Regulation of circadian sleep/wake cycle, non-REM sleepdefinition[GO:0045188] silver  
  • IEAOrtholog Compara
Regulation of circadian sleep/wake cycle, REM sleepdefinition[GO:0042320]  
  • ISSOrtholog Curator
Regulation of dendrite morphogenesisdefinition[GO:0048814]  
  • ISSOrtholog Curator
Regulation of dopamine metabolic processdefinition[GO:0042053]  
  • ISSOrtholog Curator
Regulation of dopamine secretiondefinition[GO:0014059]  
  • ISSOrtholog Curator
Regulation of synapse assemblydefinition[GO:0051963]  
  • ISSOrtholog Curator
Regulation of synaptic transmission, dopaminergicdefinition[GO:0032225]  
  • ISSOrtholog Curator
Response to cocainedefinition[GO:0042220]  
  • ISSOrtholog Curator
Response to ethanoldefinition[GO:0045471]  
  • ISSOrtholog Curator
Response to hypoxiadefinition[GO:0001666]  
1
  • IDAUniProtKB
Response to nicotinedefinition[GO:0035094]  
1
  • IDAUniProtKB
Sensory perception of paindefinition[GO:0019233]  
  • ISSOrtholog Curator
Sensory perception of sounddefinition[GO:0007605]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • IDAUniProtKB
Smooth muscle contractiondefinition[GO:0006939]  
  • ISSOrtholog Curator
Social behaviordefinition[GO:0035176]  
  • ISSOrtholog Curator
Synaptic transmission involved in micturitiondefinition[GO:0060084]  
  • ISSOrtholog Curator
Synaptic transmission, cholinergicdefinition[GO:0007271]  
  • ISSOrtholog Curator
Vestibulocochlear nerve developmentdefinition[GO:0021562]  
  • ISSOrtholog Curator
Visual learningdefinition[GO:0008542]  
1
  • IMPUniProtKB
Visual perceptiondefinition[GO:0007601]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+1141  
Neuroactive ligand-receptor interaction  hsa04080+1141  
According to Reactome, this protein belongs to the following pathways:
Highly calcium permeable nicotinic acetylcholine receptors  REACT_22352  
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors  REACT_22303  
Highly sodium permeable acetylcholine nicotinic receptors  REACT_22223  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CHRNB2
GenomeRNAi: 1141
PRO: PR:P17787
Chemistry
GuidetoPHARMACOLOGY: 472