CTPS1 - CTP synthase 1 - human protein (Function)
 
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Protein
Gene
References

 
CTPS1 »  CTP synthase 1   [ EC 6.3.4.2 ]
 
Protein also known as:  UTP--ammonia ligase 1.
Gene name:  CTPS1
Family name: CTP synthase
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.  
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  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
CTP synthase activitydefinition[GO:0003883]  
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  • UniProtKB
GO biological process 
'de novo' CTP biosynthetic processdefinition[GO:0044210]  
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  • UniPathway
B cell proliferationdefinition[GO:0042100]  
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  • UniProtKB
CTP biosynthetic processdefinition[GO:0006241]  
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  • UniProtKB
Glutamine metabolic processdefinition[GO:0006541]  
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  • UniProtKB KW
Nucleobase-containing compound metabolic processdefinition[GO:0006139]  
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  • PINC
Response to drugdefinition[GO:0042493]  
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  • PINC
T cell proliferationdefinition[GO:0042098]  
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  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.3.4.2: ATP + UTP + L-glutamine ADP + phosphate + CTP + L-glutamate.  
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  • UniProtKB
It is regulated in the following manner
Activated by GTP and inhibited by CTP.  
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  • UniProtKB
Pathways 
This protein is involved in the following pathway
Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2  
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  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+1503  
Pyrimidine metabolism  hsa00240+1503  
According to Reactome, this protein belongs to the following pathway:
Synthesis and interconversion of nucleotide di- and triphosphates  REACT_21330  
 
More information is available from:
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Pyrimidine biosynthesis  definition   [KW-0665]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CTP_synthase_1
GenomeRNAi: 1503
PRO: PR:P17812