ENG - Endoglin - human protein (Function)
 
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ENG »  Endoglin
 
Protein also known as:  CD antigen CD105.
Gene name:  ENG
Entry whose protein(s) existence is based on evidence at protein level
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1 256 2
GENE REF ISO

Function

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Overview 
Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3.  
2
  • CuratedUniProtKB
GO molecular function 
Activin bindingdefinition[GO:0048185]  
1
  • TASBHF-UCL
Galactose bindingdefinition[GO:0005534]  
1
  • IDABHF-UCL
Glycosaminoglycan bindingdefinition[GO:0005539]  
2
  • ISSBHF-UCL
Contributes to protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIHGNC
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
  • IEAOrtholog Compara
Transforming growth factor beta bindingdefinition[GO:0050431]  
2
  • IPIBHF-UCL
Transforming growth factor beta receptor, cytoplasmic mediator activitydefinition[GO:0005072]  
1
  • IDABHF-UCL
Isoform  Long   Transforming growth factor beta-activated receptor activitydefinition[GO:0005024]  
1
  • IDABHF-UCL
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • NASBHF-UCL
Type I transforming growth factor beta receptor bindingdefinition[GO:0034713]  
3
  • IPIBHF-UCL
Type II transforming growth factor beta receptor bindingdefinition[GO:0005114]  
2
  • IPIBHF-UCL
GO biological process 
Artery morphogenesisdefinition[GO:0048844]  
1
  • ISSBHF-UCL
BMP signaling pathwaydefinition[GO:0030509]  
1
  • TASBHF-UCL
Bone developmentdefinition[GO:0060348] silver  
  • IEAOrtholog Compara
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Isoform  Long   Cell chemotaxisdefinition[GO:0060326]  
1
  • IMPBHF-UCL
Isoform  Long   Cell migrationdefinition[GO:0016477]  
1
  • IMPBHF-UCL
Cell migration involved in endocardial cushion formationdefinition[GO:0003273] silver  
  • IEAOrtholog Compara
Isoform  Long   Cell motilitydefinition[GO:0048870]  
1
  • IMPBHF-UCL
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
  • IEAOrtholog Compara
Central nervous system vasculogenesisdefinition[GO:0022009]  
1
  • IMPBHF-UCL
Chronological cell agingdefinition[GO:0001300]  
1
  • IEPBHF-UCL
  • IEAOrtholog Compara
Detection of hypoxiadefinition[GO:0070483]  
1
  • IDABHF-UCL
Extracellular matrix constituent secretiondefinition[GO:0070278] silver  
  • IEAOrtholog Compara
Isoform  Long   Extracellular matrix disassemblydefinition[GO:0022617]  
1
  • IMPBHF-UCL
Heart loopingdefinition[GO:0001947]  
1
  • ISSBHF-UCL
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IDAGOC
Isoform  Long   Metabolic processdefinition[GO:0008152]  
1
  • IDAGOC
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • IDABHF-UCL
Isoform  Short   Negative regulation of endothelial cell proliferationdefinition[GO:0001937]  
1
  • IMPBHF-UCL
Isoform  Short   Negative regulation of nitric-oxide synthase activitydefinition[GO:0051001]  
1
  • IMPBHF-UCL
Isoform  Long   Negative regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0060394]  
1
  • IMPBHF-UCL
Negative regulation of protein autophosphorylationdefinition[GO:0031953]  
1
  • IDABHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDABHF-UCL
Negative regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0030512]  
1
  • TASBHF-UCL
Patterning of blood vesselsdefinition[GO:0001569]  
1
  • ISSBHF-UCL
Isoform  Long   Phosphorylationdefinition[GO:0016310]  
1
  • IDAGOC
Positive regulation of BMP signaling pathwaydefinition[GO:0030513]  
1
  • IDABHF-UCL
Positive regulation of collagen biosynthetic processdefinition[GO:0032967] silver  
  • IEAOrtholog Compara
Positive regulation of gene expressiondefinition[GO:0010628] silver  
  • IEAOrtholog Compara
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
2
  • IMPBHF-UCL
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • IDABHF-UCL
Isoform  Short   Positive regulation of systemic arterial blood pressuredefinition[GO:0003084]  
1
  • IMPBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Isoform  Long   Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAGOC
Regulation of cell adhesiondefinition[GO:0030155]  
1
  • TASBHF-UCL
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • TASBHF-UCL
Regulation of phosphorylationdefinition[GO:0042325]  
1
  • TASBHF-UCL
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IMPHGNC
Regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0017015]  
1
  • IDAHGNC
Response to corticosteroiddefinition[GO:0031960] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666]  
1
  • IDABHF-UCL
Response to statindefinition[GO:0036273] silver  
  • IEAOrtholog Compara
Response to transforming growth factor betadefinition[GO:0071559] silver  
  • IEAOrtholog Compara
Smooth muscle tissue developmentdefinition[GO:0048745]  
1
  • ISSBHF-UCL
Isoform  Long but not isoform  Short   Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
1
  • IDABHF-UCL
Vasculogenesisdefinition[GO:0001570]  
1
  • IMPBHF-UCL
Venous blood vessel morphogenesisdefinition[GO:0048845]  
1
  • ISSBHF-UCL
Isoform  Long   Wound healingdefinition[GO:0042060]  
1
  • IMPBHF-UCL
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Endoglin
GenomeRNAi: 2022
PRO: PR:P17813