XBP1 - X-box-binding protein 1 - human protein (Function)
 
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XBP1 »  X-box-binding protein 1
 
Gene name:  XBP1
Family name: bZIP
Entry whose protein(s) existence is based on evidence at protein level
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1 116 2
GENE REF ISO

Function

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Overview 
Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I.  
5
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • TASPINC
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Cellular response to antibioticdefinition[GO:0071236] silver  
  • IEAOrtholog Compara
Epithelial cell maturation involved in salivary gland developmentdefinition[GO:0060691] silver  
  • IEAOrtholog Compara
Exocrine pancreas developmentdefinition[GO:0031017] silver  
  • IEAOrtholog Compara
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Positive regulation of endoplasmic reticulum unfolded protein responsedefinition[GO:1900103]  
1
  • IMPUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to electrical stimulusdefinition[GO:0051602] silver  
  • IEAOrtholog Compara
Serotonin secretion, neurotransmissiondefinition[GO:0060096] silver  
  • IEAOrtholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
HTLV-I infection  hsa05166+7494  
Protein processing in endoplasmic reticulum  hsa04141+7494  
According to Reactome, this protein belongs to the following pathways:
ATF6-alpha activates chaperone genes  REACT_18423  
IRE1alpha activates chaperones  REACT_18368  
XBP1(S) activates chaperone genes  REACT_18273  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: XBP1
GenomeRNAi: 7494
PRO: PR:P17861