XBP1 - X-box-binding protein 1 - human protein (Function)
 
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XBP1 »  X-box-binding protein 1  (XBP-1)
 
Protein also known as:  Tax-responsive element-binding protein 5 (TREB-5). Cleaved into:  X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form.
Gene name:  XBP1
Family name: bZIP
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 139 2
GENE REF ISO

Function

 show evidences
Overview 
Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed11460154). Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed20348923). Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed8349596). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity).  
5
  • UniProtKB
GO molecular function 
Chromatin DNA bindingdefinition[GO:0031490]  
1
  • UniProtKB
Core promoter bindingdefinition[GO:0001047]  
1
  • Ortholog Curator
DNA bindingdefinition[GO:0003677]  
1
  • PINC
Enhancer sequence-specific DNA bindingdefinition[GO:0001158]  
1
  • UniProtKB
Isoform  Iso 2   Estrogen receptor bindingdefinition[GO:0030331]  
1
  • ParkinsonsUK-UCL
Isoform  Iso 1   Protease bindingdefinition[GO:0002020]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
2
  • ParkinsonsUK-UCL
  • UniProtKB
Isoform  Iso 2   Protein homodimerization activitydefinition[GO:0042803]  
1
  • ParkinsonsUK-UCL
Isoform  Iso 2   Protein kinase bindingdefinition[GO:0019901]  
1
  • UniProtKB
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • UniProtKB
RNA polymerase II transcription factor bindingdefinition[GO:0001085] silver  
1
  • Ortholog Compara
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981] silver  
1
  • Ortholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • ParkinsonsUK-UCL
  • UniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
2
  • UniProtKB
Isoform  Iso 1   Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • UniProtKB
GO biological process 
Adipose tissue developmentdefinition[GO:0060612]  
1
  • Ortholog Curator
Angiogenesisdefinition[GO:0001525]  
1
  • Ortholog Curator
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB KW
Autophagydefinition[GO:0006914]  
1
  • UniProtKB KW
Isoform  Iso 2   Cell growthdefinition[GO:0016049]  
1
  • UniProtKB
Cellular response to amino acid stimulusdefinition[GO:0071230]  
1
  • Ortholog Curator
Cellular response to antibioticdefinition[GO:0071236] silver  
1
  • Ortholog Compara
Cellular response to fluid shear stressdefinition[GO:0071498]  
2
  • UniProtKB
Cellular response to fructose stimulusdefinition[GO:0071332]  
1
  • Ortholog Curator
Cellular response to glucose starvationdefinition[GO:0042149]  
1
  • Ortholog Curator
Cellular response to glucose stimulusdefinition[GO:0071333]  
1
  • Ortholog Curator
Cellular response to insulin stimulusdefinition[GO:0032869]  
1
  • Ortholog Curator
Cellular response to interleukin-4definition[GO:0071353]  
1
  • Ortholog Curator
Cellular response to laminar fluid shear stressdefinition[GO:0071499]  
1
  • UniProtKB
Cellular response to lipopolysaccharidedefinition[GO:0071222]  
1
  • UniProtKB
Cellular response to nutrientdefinition[GO:0031670]  
1
  • Ortholog Curator
Isoform  Iso 1   Cellular response to oxidative stressdefinition[GO:0034599]  
1
  • UniProtKB
Cellular response to peptide hormone stimulusdefinition[GO:0071375]  
1
  • Ortholog Curator
Cellular response to vascular endothelial growth factor stimulusdefinition[GO:0035924]  
1
  • UniProtKB
Cellular triglyceride homeostasisdefinition[GO:0035356]  
1
  • Ortholog Curator
Cholesterol homeostasisdefinition[GO:0042632]  
1
  • Ortholog Curator
Endoplasmic reticulum unfolded protein responsedefinition[GO:0030968]  
1
  • Ortholog Curator
Isoform  Iso 2   Endothelial cell proliferationdefinition[GO:0001935]  
1
  • UniProtKB
Epithelial cell maturation involved in salivary gland developmentdefinition[GO:0060691] silver  
1
  • Ortholog Compara
Exocrine pancreas developmentdefinition[GO:0031017] silver  
1
  • Ortholog Compara
Fatty acid biosynthetic processdefinition[GO:0006633]  
1
  • ParkinsonsUK-UCL
Fatty acid homeostasisdefinition[GO:0055089]  
1
  • Ortholog Curator
Immune responsedefinition[GO:0006955]  
1
  • ParkinsonsUK-UCL
IRE1-mediated unfolded protein responsedefinition[GO:0036498]  
2
  • ParkinsonsUK-UCL
Liver developmentdefinition[GO:0001889]  
1
  • Ortholog Curator
Muscle organ developmentdefinition[GO:0007517]  
1
  • UniProtKB KW
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • Ortholog Curator
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwaydefinition[GO:1902236]  
1
  • ParkinsonsUK-UCL
Isoform  Iso 1   Negative regulation of endoplasmic reticulum unfolded protein responsedefinition[GO:1900102]  
1
  • UniProtKB
Negative regulation of myotube differentiationdefinition[GO:0010832]  
1
  • Ortholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
3
  • UniProtKB
Neuron developmentdefinition[GO:0048666]  
1
  • Ortholog Curator
Isoform  Iso 2   Organelle organizationdefinition[GO:0006996]  
1
  • ParkinsonsUK-UCL
Isoform  Iso 2   Phosphatidylinositol 3-kinase signalingdefinition[GO:0014065]  
1
  • UniProtKB
Isoform  Iso 2   Positive regulation of autophagydefinition[GO:0010508]  
1
  • UniProtKB
Positive regulation of B cell differentiationdefinition[GO:0045579]  
1
  • UniProtKB
Positive regulation of endoplasmic reticulum unfolded protein responsedefinition[GO:1900103]  
1
  • UniProtKB
Isoform  Iso 2   Positive regulation of endothelial cell apoptotic processdefinition[GO:2000353]  
1
  • UniProtKB
Isoform  Iso 2   Positive regulation of ER-associated ubiquitin-dependent protein catabolic processdefinition[GO:1903071]  
1
  • ParkinsonsUK-UCL
Positive regulation of fat cell differentiationdefinition[GO:0045600]  
1
  • Ortholog Curator
Positive regulation of hepatocyte proliferationdefinition[GO:2000347]  
1
  • Ortholog Curator
Isoform  Iso 2   Positive regulation of histone methylationdefinition[GO:0031062]  
1
  • UniProtKB
Positive regulation of immunoglobulin productiondefinition[GO:0002639]  
1
  • UniProtKB
Positive regulation of immunoglobulin secretiondefinition[GO:0051024]  
1
  • Ortholog Curator
Positive regulation of interleukin-6 secretiondefinition[GO:2000778]  
1
  • Ortholog Curator
Positive regulation of lactationdefinition[GO:1903489]  
1
  • Ortholog Curator
Positive regulation of MHC class II biosynthetic processdefinition[GO:0045348]  
1
  • UniProtKB
Isoform  Iso 2   Positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoterdefinition[GO:1900413]  
1
  • ParkinsonsUK-UCL
Positive regulation of plasma cell differentiationdefinition[GO:1900100]  
1
  • UniProtKB
Positive regulation of proteasomal protein catabolic processdefinition[GO:1901800] silver  
1
  • Ortholog Compara
Isoform  Iso 2   Positive regulation of protein acetylationdefinition[GO:1901985]  
1
  • UniProtKB
Isoform  Iso 1   Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • UniProtKB
Positive regulation of T cell differentiationdefinition[GO:0045582]  
1
  • UniProtKB
Isoform  Iso 1   Positive regulation of TOR signalingdefinition[GO:0032008]  
1
  • UniProtKB
Isoform  Iso 1   Positive regulation of transcription factor import into nucleusdefinition[GO:0042993]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
7
  • UniProtKB
  • ParkinsonsUK-UCL
  • Ortholog Curator
Isoform  Iso 2   Positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stressdefinition[GO:1990440]  
1
  • ParkinsonsUK-UCL
Positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein responsedefinition[GO:0006990]  
2
  • UniProtKB
  • Ortholog Curator
Protein destabilizationdefinition[GO:0031648]  
3
  • UniProtKB
Protein transportdefinition[GO:0015031]  
1
  • UniProtKB KW
Isoform  Iso 1   Regulation of protein stabilitydefinition[GO:0031647]  
1
  • UniProtKB
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to electrical stimulusdefinition[GO:0051602] silver  
1
  • Ortholog Compara
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
4
  • UniProtKB
Response to insulin-like growth factor stimulusdefinition[GO:1990418]  
1
  • Ortholog Curator
Serotonin secretion, neurotransmissiondefinition[GO:0060096] silver  
1
  • Ortholog Compara
Sterol homeostasisdefinition[GO:0055092]  
1
  • Ortholog Curator
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • Ortholog Curator
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511]  
1
  • Ortholog Curator
Isoform  Iso 2   Vascular endothelial growth factor receptor signaling pathwaydefinition[GO:0048010]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
HTLV-I infection  hsa05166+7494  
Protein processing in endoplasmic reticulum  hsa04141+7494  
According to Reactome, this protein belongs to the following pathways:
ATF6-alpha activates chaperone genes  REACT_18423  
IRE1alpha activates chaperones  REACT_18368  
XBP1(S) activates chaperone genes  REACT_18273  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Apoptosis  definition   [KW-0053]
Autophagy  definition   [KW-0072]
Differentiation  definition   [KW-0221]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Myogenesis  definition   [KW-0517]
Protein transport  definition   [KW-0653]
Stress response  definition   [KW-0346]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Transport  definition   [KW-0813]
Unfolded protein response  definition   [KW-0834]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: XBP1
GenomeRNAi: 7494
PRO: PR:P17861