GM2A - Ganglioside GM2 activator - human protein (Function)
 
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Protein
Gene
References

 
GM2A »  Ganglioside GM2 activator
 
Protein also known as:  Cerebroside sulfate activator protein. Cleaved into:  Ganglioside GM2 activator isoform short.
Gene name:  GM2A
Entry whose protein(s) existence is based on evidence at protein level
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1 33 1
GENE REF ISO

Function

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Overview 
The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.  
  • CuratedUniProtKB
GO molecular function 
Beta-N-acetylhexosaminidase activitydefinition[GO:0004563] silver  
  • IEAOrtholog Compara
Lipid transporter activitydefinition[GO:0005319] silver  
  • IEAOrtholog Compara
Phospholipase activator activitydefinition[GO:0016004] silver  
  • IEAOrtholog Compara
GO biological process 
Ganglioside catabolic processdefinition[GO:0006689] silver  
  • IEAOrtholog Compara
Learning or memorydefinition[GO:0007611] silver  
  • IEAOrtholog Compara
Lipid storagedefinition[GO:0019915] silver  
  • IEAOrtholog Compara
Neuromuscular process controlling balancedefinition[GO:0050885] silver  
  • IEAOrtholog Compara
Oligosaccharide catabolic processdefinition[GO:0009313] silver  
  • IEAOrtholog Compara
Positive regulation of hydrolase activitydefinition[GO:0051345] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Lysosome  hsa04142+2760  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Lipid metabolism  definition   [KW-0443]
Sphingolipid metabolism  definition   [KW-0746]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GM2A
GenomeRNAi: 2760
PRO: PR:P17900