CR1 - Complement receptor type 1 - human protein (Function)
 
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CR1 »  Complement receptor type 1
 
Protein also known as:  C3b/C4b receptor; CD antigen CD35.
Gene name:  CR1
Entry whose protein(s) existence is based on evidence at protein level
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1 114 1
GENE REF ISO

Function

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Overview 
Mediates cellular binding of particles and immune complexes that have activated complement.  
  • CuratedUniProtKB
GO molecular function 
Complement component C3b bindingdefinition[GO:0001851]  
1
  • IDAUniProtKB
Complement component C3b receptor activitydefinition[GO:0004877]  
1
  • IDAUniProtKB
Complement component C4b bindingdefinition[GO:0001855]  
1
  • IDAUniProtKB
Complement component C4b receptor activitydefinition[GO:0001861]  
1
  • IDAUniProtKB
GO biological process 
Complement activation, classical pathwaydefinition[GO:0006958]  
  • IEAUniProtKB KW
Complement receptor mediated signaling pathwaydefinition[GO:0002430]  
1
  • IDAGOC
Negative regulation of complement activation, alternative pathwaydefinition[GO:0045957]  
1
  • IDAUniProtKB
Negative regulation of complement activation, classical pathwaydefinition[GO:0045959]  
2
  • IDAUniProtKB
Negative regulation of serine-type endopeptidase activitydefinition[GO:1900004]  
1
  • IDAUniProtKB
Positive regulation of serine-type endopeptidase activitydefinition[GO:1900005]  
1
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • IDAGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Complement and coagulation cascades  hsa04610+1378  
Hematopoietic cell lineage  hsa04640+1378  
Legionellosis  hsa05134+1378  
Leishmaniasis  hsa05140+1378  
Malaria  hsa05144+1378  
Tuberculosis  hsa05152+1378  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Complement pathway  definition   [KW-0180]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Molecular function 
Blood group antigen  definition   [KW-0095]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Complement_receptor_1
GenomeRNAi: 1378
PRO: PR:P17927