IGFBP2 - Insulin-like growth factor-binding protein 2 - human protein (Function)
 
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IGFBP2 »  Insulin-like growth factor-binding protein 2  (IBP-2)
 
Gene name:  IGFBP2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.  
1
  • CuratedUniProtKB
GO molecular function 
Insulin-like growth factor I bindingdefinition[GO:0031994]  
1
  • IDAUniProtKB
Insulin-like growth factor II bindingdefinition[GO:0031995]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Cellular response to hormone stimulusdefinition[GO:0032870] silver  
  • IEAOrtholog Compara
Female pregnancydefinition[GO:0007565] silver  
  • IEAOrtholog Compara
Positive regulation of activated T cell proliferationdefinition[GO:0042104]  
1
  • IDABHF-UCL
Regulation of cell growthdefinition[GO:0001558] silver  
  • IEAInterPro 2 GO
Regulation of insulin-like growth factor receptor signaling pathwaydefinition[GO:0043567]  
1
  • ICUniProtKB
  • ISSOrtholog Curator
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to lithium iondefinition[GO:0010226] silver  
  • IEAOrtholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Response to retinoic aciddefinition[GO:0032526] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165] silver  
  • IEAOrtholog Compara
Enzymatic activity 
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
 

Keywords

Biological process 
Growth regulation  definition   [KW-0341]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IGFBP2
GenomeRNAi: 3485
PRO: PR:P18065