IGFBP2 - Insulin-like growth factor-binding protein 2 - human protein (Function)
 
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IGFBP2 »  Insulin-like growth factor-binding protein 2  (IBP-2)
 
Gene name:  IGFBP2
Entry whose protein(s) existence is based on evidence at protein level
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1 131 1
GENE REF ISO

Function

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Overview 
Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.  
2
  • UniProtKB
GO molecular function 
Insulin-like growth factor I bindingdefinition[GO:0031994]  
1
  • UniProtKB
Insulin-like growth factor II bindingdefinition[GO:0031995]  
2
  • RefGenome
  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Cellular response to hormone stimulusdefinition[GO:0032870] silver  
1
  • Ortholog Compara
Female pregnancydefinition[GO:0007565] silver  
1
  • Ortholog Compara
Positive regulation of activated T cell proliferationdefinition[GO:0042104]  
1
  • BHF-UCL
Regulation of cell growthdefinition[GO:0001558] silver  
1
  • InterPro 2 GO
Regulation of insulin-like growth factor receptor signaling pathwaydefinition[GO:0043567]  
3
  • UniProtKB
  • RefGenome
  • Ortholog Curator
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to estradioldefinition[GO:0032355] silver  
1
  • Ortholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
1
  • Ortholog Compara
Response to lithium iondefinition[GO:0010226] silver  
1
  • Ortholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
1
  • Ortholog Compara
Response to nutrientdefinition[GO:0007584] silver  
1
  • Ortholog Compara
Response to retinoic aciddefinition[GO:0032526] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165] silver  
1
  • Ortholog Compara
Enzymatic activity 
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)  REACT_15428  
 

Keywords

Biological process 
Growth regulation  definition   [KW-0341]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IGFBP2
GenomeRNAi: 3485
PRO: PR:P18065