ERCC2 - TFIIH basal transcription factor complex helicase XPD subunit - human protein (Function)
 
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ERCC2 »  TFIIH basal transcription factor complex helicase XPD subunit   [ EC 3.6.4.12 ]
 
Protein also known as:  TFIIH basal transcription factor complex 80 kDa subunit (TFIIH p80).
Gene name:  ERCC2
Family name: Helicase » RAD3/XPD
Entry whose protein(s) existence is based on evidence at protein level
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1 267 2
GENE REF ISO

Function

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Overview 
ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.  
4
  • CuratedUniProtKB
GO molecular function 
4 iron, 4 sulfur cluster bindingdefinition[GO:0051539]  
  • IEAUniProtKB KW
5'-3' DNA helicase activitydefinition[GO:0043139]  
2
  • IDAUniProtKB
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATP-dependent DNA helicase activitydefinition[GO:0004003] silver  
  • IEAInterPro 2 GO
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Contributes to DNA-dependent ATPase activitydefinition[GO:0008094]  
2
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • IPIUniProtKB
Contributes to protein kinase activitydefinition[GO:0004672]  
1
  • IDAUniProtKB
Protein N-terminus bindingdefinition[GO:0047485]  
1
  • IPIUniProtKB
Contributes to RNA polymerase II carboxy-terminal domain kinase activitydefinition[GO:0008353]  
1
  • IDAUniProtKB
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Apoptotic processdefinition[GO:0006915]  
1
  • IMPUniProtKB
ATP catabolic processdefinition[GO:0006200]  
2
  • IDAGOC
  • IEAInterPro 2 GO
Bone mineralizationdefinition[GO:0030282] silver  
  • IEAOrtholog Compara
Cell proliferationdefinition[GO:0008283] silver  
  • IEAOrtholog Compara
Central nervous system myelin formationdefinition[GO:0032289] silver  
  • IEAOrtholog Compara
Chromosome segregationdefinition[GO:0007059]  
1
  • IMPUniProtKB
DNA duplex unwindingdefinition[GO:0032508]  
2
  • IDAGOC
  • IEAInterPro 2 GO
Embryonic cleavagedefinition[GO:0040016] silver  
  • IEAOrtholog Compara
Erythrocyte maturationdefinition[GO:0043249] silver  
  • IEAOrtholog Compara
Extracellular matrix organizationdefinition[GO:0030198] silver  
  • IEAOrtholog Compara
Hair cell differentiationdefinition[GO:0035315]  
1
  • IMPUniProtKB
Hair follicle maturationdefinition[GO:0048820] silver  
  • IEAOrtholog Compara
Hematopoietic stem cell differentiationdefinition[GO:0060218] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Multicellular organism growthdefinition[GO:0035264] silver  
  • IEAOrtholog Compara
Nucleotide-excision repairdefinition[GO:0006289]  
2
  • NASUniProtKB
  • IGIMGI
Nucleotide-excision repair, DNA incisiondefinition[GO:0033683]  
1
  • IMPUniProtKB
Positive regulation of DNA bindingdefinition[GO:0043388] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Post-embryonic developmentdefinition[GO:0009791] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAGOC
Regulation of mitotic cell cycle phase transitiondefinition[GO:1901990]  
1
  • IMPUniProtKB
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to oxidative stressdefinition[GO:0006979]  
1
  • IMPUniProtKB
Spinal cord developmentdefinition[GO:0021510] silver  
  • IEAOrtholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
2
  • IDAUniProtKB
Transcription-coupled nucleotide-excision repairdefinition[GO:0006283]  
1
  • IDAUniProtKB
UV protectiondefinition[GO:0009650]  
1
  • IGIMGI
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.4.12: ATP + H(2)O ADP + phosphate.  
  • CuratedUniProtKB
It requires the following cofactors
Magnesium.  
1
  • CuratedUniProtKB
Binds 1 4Fe-4S cluster.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal transcription factors  hsa03022+2068  
Nucleotide excision repair  hsa03420+2068  
According to Reactome, this protein belongs to the following pathways:
Cytosolic iron-sulfur cluster assembly  REACT_160176  
Dual incision reaction in GG-NER  REACT_311  
Dual incision reaction in TC-NER  REACT_2222  
Formation of HIV elongation complex in the absence of HIV Tat  REACT_22201  
Formation of HIV-1 elongation complex containing HIV-1 Tat  REACT_6346  
Formation of incision complex in GG-NER  REACT_257  
Formation of the Early Elongation Complex  REACT_846  
Formation of the HIV-1 Early Elongation Complex  REACT_6319  
Formation of transcription-coupled NER (TC-NER) repair complex  REACT_1941  
HIV Transcription Initiation  REACT_6332  
mRNA Capping  REACT_1470  
NoRC negatively regulates rRNA expression  REACT_200856  
RNA Pol II CTD phosphorylation and interaction with CE  REACT_6237  
RNA Pol II CTD phosphorylation and interaction with CE  REACT_975  
RNA Polymerase I Chain Elongation  REACT_2204  
RNA Polymerase I Promoter Escape  REACT_1913  
RNA Polymerase I Transcription Initiation  REACT_953  
RNA Polymerase I Transcription Termination  REACT_1074  
RNA Polymerase II HIV Promoter Escape  REACT_6253  
RNA Polymerase II Pre-transcription Events  REACT_22107  
RNA Polymerase II Promoter Escape  REACT_2089  
RNA Polymerase II Transcription Elongation  REACT_833  
RNA Polymerase II Transcription Initiation  REACT_1851  
RNA Polymerase II Transcription Initiation And Promoter Clearance  REACT_834  
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening  REACT_1655  
Tat-mediated elongation of the HIV-1 transcript  REACT_6162  
Transcription of the HIV genome  REACT_6233  
 

Keywords

Biological process 
Chromosome partition  definition   [KW-0159]
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ERCC2
GenomeRNAi: 2068
PRO: PR:P18074