ADRA2B - Alpha-2B adrenergic receptor - human protein (Function)
 
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ADRA2B »  Alpha-2B adrenergic receptor
 
Protein also known as:  Alpha-2 adrenergic receptor subtype C2.
Gene name:  ADRA2B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.  
1
  • CuratedUniProtKB
GO molecular function 
Alpha2-adrenergic receptor activitydefinition[GO:0004938]  
1
  • IDABHF-UCL
Epinephrine bindingdefinition[GO:0051379]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
GO biological process 
Activation of MAPK activity by adrenergic receptor signaling pathwaydefinition[GO:0071883]  
1
  • IDABHF-UCL
Activation of protein kinase B activitydefinition[GO:0032148]  
1
  • IDABHF-UCL
Angiogenesisdefinition[GO:0001525] silver  
  • IEAOrtholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwaydefinition[GO:0035625]  
1
  • IDABHF-UCL
Female pregnancydefinition[GO:0007565] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
MAPK cascadedefinition[GO:0000165] silver  
  • IEAOrtholog Compara
Negative regulation of epinephrine secretiondefinition[GO:0032811]  
1
  • NASBHF-UCL
Negative regulation of norepinephrine secretiondefinition[GO:0010700]  
2
  • TASBHF-UCL
Positive regulation of blood pressuredefinition[GO:0045777] silver  
  • IEAOrtholog Compara
Positive regulation of neuron differentiationdefinition[GO:0045666]  
1
  • IDABHF-UCL
Positive regulation of uterine smooth muscle contractiondefinition[GO:0070474] silver  
  • IEAOrtholog Compara
Regulation of vascular smooth muscle contractiondefinition[GO:0003056] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+151  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Alpha-2B_adrenergic_receptor
GenomeRNAi: 151
PRO: PR:P18089
Chemistry
GuidetoPHARMACOLOGY: 26