VCL - Vinculin - human protein (Function)
 
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Protein
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References

 
VCL »  Vinculin
 
Protein also known as:  Metavinculin (MV).
Gene name:  VCL
Family name: Vinculin/alpha-catenin
Entry whose protein(s) existence is based on evidence at protein level
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1 106 3
GENE REF ISO

Function

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Overview 
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.  
2
  • CuratedUniProtKB
GO molecular function 
Contradiction  Actin bindingdefinition[GO:0003779]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Alpha-catenin bindingdefinition[GO:0045294]  
1
  • IPIUniProtKB
Beta-catenin bindingdefinition[GO:0008013]  
1
  • ISSBHF-UCL
Cadherin bindingdefinition[GO:0045296]  
1
  • ISSBHF-UCL
Dystroglycan bindingdefinition[GO:0002162]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
13
  • IPIUniProtKB
  • IPIIntAct
  • IPIBHF-UCL
Structural molecule activitydefinition[GO:0005198] silver  
  • IEAInterPro 2 GO
GO biological process 
Adherens junction assemblydefinition[GO:0034333]  
1
  • IMPBHF-UCL
Apical junction assemblydefinition[GO:0043297]  
1
  • IMPUniProtKB
Cell adhesiondefinition[GO:0007155]  
1
  • TASUniProtKB
Cell-matrix adhesiondefinition[GO:0007160]  
1
  • TASBHF-UCL
Cellular component movementdefinition[GO:0006928]  
1
  • TASUniProtKB
Epithelial cell-cell adhesiondefinition[GO:0090136]  
1
  • IMPBHF-UCL
Lamellipodium assemblydefinition[GO:0030032]  
  • ISSOrtholog Curator
Morphogenesis of an epitheliumdefinition[GO:0002009]  
1
  • IMPBHF-UCL
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • TASUniProtKB
Protein localization to cell surfacedefinition[GO:0034394]  
1
  • IMPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+7414  
Amoebiasis  hsa05146+7414  
Bacterial invasion of epithelial cells  hsa05100+7414  
Focal adhesion  hsa04510+7414  
Leukocyte transendothelial migration  hsa04670+7414  
Regulation of actin cytoskeleton  hsa04810+7414  
Shigellosis  hsa05131+7414  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Muscle contraction  REACT_17044  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Vinculin
GenomeRNAi: 7414
PRO: PR:P18206